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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rgf BAX Cyclin-dependent kinase 8 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 1.302
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.790
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.783
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.779
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.776
3ugc 046Tyrosine-protein kinase JAK2 / 0.773
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.764
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.763
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.746
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.739
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.730
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.725
3gcs BAXMitogen-activated protein kinase 14 / 0.721
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.717
4o2z 046Mitogen-activated protein kinase / 0.716
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.713
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.708
3gi3 B10Mitogen-activated protein kinase 14 / 0.704
3gcq 1BUMitogen-activated protein kinase 14 / 0.692
3hv3 R49Mitogen-activated protein kinase 14 / 0.690
4ja8 1K9Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.687
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.684
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.683
3nnx EDDMitogen-activated protein kinase 14 / 0.682
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.682
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.680
3uvr 06FMitogen-activated protein kinase 14 / 0.679
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.679
3el7 PD3Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.675
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.675
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3p7c P7CMitogen-activated protein kinase 14 / 0.667
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.665
3p5k P5KMitogen-activated protein kinase 14 / 0.663
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.662
3hv6 R39Mitogen-activated protein kinase 14 / 0.661
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.660
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.659
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3lff Z83Mitogen-activated protein kinase 14 / 0.658
3p7b P7BMitogen-activated protein kinase 14 / 0.658
1w82 L10Mitogen-activated protein kinase 14 / 0.657
2yis YISMitogen-activated protein kinase 14 / 0.653
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.653
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.653
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.653
3hv4 L51Mitogen-activated protein kinase 14 / 0.652
3tuc FPWTyrosine-protein kinase SYK 2.7.10.2 0.652
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.652
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.650