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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3r6t LU1 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3r6t LU1Catechol O-methyltransferase 2.1.1.6 1.241
3nw9 637Catechol O-methyltransferase 2.1.1.6 1.062
3hvi 619Catechol O-methyltransferase 2.1.1.6 1.054
3nwb 659Catechol O-methyltransferase 2.1.1.6 1.054
3nwe 662Catechol O-methyltransferase 2.1.1.6 1.036
3hvk 719Catechol O-methyltransferase 2.1.1.6 1.018
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.933
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.872
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.859
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.846
3a7d FBNCatechol O-methyltransferase 2.1.1.6 0.826
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.792
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.782
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.721
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.714
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.702
2cl5 BIECatechol O-methyltransferase 2.1.1.6 0.698
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.680
4yuz S4MSpermidine synthase, putative / 0.664
3duw SAHO-methyltransferase, putative / 0.653
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.653
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.652
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.650
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.650