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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qyz Z8B Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.874
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.789
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.771
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.739
3tei ANPMitogen-activated protein kinase 1 2.7.11.24 0.729
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.715
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.701
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.691
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.690
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.685
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.682
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.673
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.665
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.661
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.659
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.657
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.656
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.653
1pf9 ADP60 kDa chaperonin / 0.652
2vo6 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1cm8 ANPMitogen-activated protein kinase 12 / 0.651
1sx4 ADP60 kDa chaperonin / 0.650
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.650