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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qyw 6PB Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qyw 6PBMitogen-activated protein kinase 1 2.7.11.24 0.850
1oiu N76Cyclin-dependent kinase 2 2.7.11.22 0.699
1h0v UN4Cyclin-dependent kinase 2 2.7.11.22 0.684
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.673
1gz8 MBPCyclin-dependent kinase 2 2.7.11.22 0.670
2vgo AD5Aurora kinase B-A 2.7.11.1 0.668
1w8c N69Cyclin-dependent kinase 2 2.7.11.22 0.667
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.660
1h1q 2A6Cyclin-dependent kinase 2 2.7.11.22 0.651
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.651
2puc GUNHTH-type transcriptional repressor PurR / 0.650