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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qri 919 Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 1.292
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.855
3gcq 1BUMitogen-activated protein kinase 14 / 0.792
3hv3 R49Mitogen-activated protein kinase 14 / 0.785
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.783
3nnw EDDMitogen-activated protein kinase 14 / 0.780
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.779
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.778
3nnx EDDMitogen-activated protein kinase 14 / 0.777
3hv6 R39Mitogen-activated protein kinase 14 / 0.774
1w82 L10Mitogen-activated protein kinase 14 / 0.763
3hv4 L51Mitogen-activated protein kinase 14 / 0.763
3hv7 1AUMitogen-activated protein kinase 14 / 0.763
3lfb Z87Mitogen-activated protein kinase 14 / 0.763
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.760
3lfe Z84Mitogen-activated protein kinase 14 / 0.757
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.755
3uvr 06FMitogen-activated protein kinase 14 / 0.753
2puu G2GMitogen-activated protein kinase 14 / 0.746
3ugc 046Tyrosine-protein kinase JAK2 / 0.746
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.738
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.737
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.737
4o2z 046Mitogen-activated protein kinase / 0.736
3lff Z83Mitogen-activated protein kinase 14 / 0.732
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.729
2yis YISMitogen-activated protein kinase 14 / 0.727
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.726
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.724
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.710
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.708
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.708
2yiw YIWMitogen-activated protein kinase 14 / 0.702
3hv5 R24Mitogen-activated protein kinase 14 / 0.699
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.698
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.697
3gcv SS6Mitogen-activated protein kinase 14 / 0.693
3gi3 B10Mitogen-activated protein kinase 14 / 0.693
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.692
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.691
3gcs BAXMitogen-activated protein kinase 14 / 0.689
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.689
3o8u BMUMitogen-activated protein kinase 14 / 0.681
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.680
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.679
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.679
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.677
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.672
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.671
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.667
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.666
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.665
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.663
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.662
3lfc Z86Mitogen-activated protein kinase 14 / 0.662
3o8p BMUMitogen-activated protein kinase 14 / 0.659
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.658
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.655
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.653
3p7a P7AMitogen-activated protein kinase 14 / 0.653
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.653
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.652
3gcu R48Mitogen-activated protein kinase 14 / 0.651