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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qlw N22 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qlw N22Dihydrofolate reductase 1.5.1.3 1.061
4h97 53SDihydrofolate reductase 1.5.1.3 0.786
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.706
3qlr QLRDihydrofolate reductase 1.5.1.3 0.670
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.666
4h95 06UDihydrofolate reductase 1.5.1.3 0.662
3qls 55VDihydrofolate reductase 1.5.1.3 0.659
3qly 55VUncharacterized protein / 0.656