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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qj7 UMP Thymidylate synthase ThyA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qj7 UMPThymidylate synthase ThyA / 1.081
2fto TMPThymidylate synthase / 0.925
4isk UMPThymidylate synthase / 0.916
4e5o UMPThymidylate synthase 2.1.1.45 0.912
4ein NOHThymidylate synthase 2.1.1.45 0.888
4h0u UMPThymidylate synthase / 0.880
4dq1 UMPThymidylate synthase / 0.870
5by6 UMPThymidylate synthase / 0.870
4fox UMPThymidylate synthase ThyA / 0.868
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.866
4irr UMPThymidylate synthase / 0.863
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.856
3bgx TMPThymidylate synthase / 0.852
4iqq UMPThymidylate synthase / 0.849
1f28 UMPThymidylate synthase 2.1.1.45 0.846
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.837
1tys TMPThymidylate synthase / 0.830
4eb4 UMPThymidylate synthase 2.1.1.45 0.824
2vet UMPThymidylate synthase / 0.790
2tsr UMPThymidylate synthase 2.1.1.45 0.787
1bid UMPThymidylate synthase / 0.772
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.769
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.758
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.757
1jmf UMPThymidylate synthase / 0.743
1vza UMPThymidylate synthase / 0.737
2g8a UMPThymidylate synthase / 0.727
1nja DCMThymidylate synthase / 0.719
2g86 UMPThymidylate synthase / 0.715
1vzb UMPThymidylate synthase / 0.714
1njc DCMThymidylate synthase / 0.700
1ci7 UMPThymidylate synthase 2.1.1.45 0.698
2g8d UMPThymidylate synthase / 0.698
1bp0 UMPThymidylate synthase / 0.697
2tdm UMPThymidylate synthase / 0.696
1jmg UMPThymidylate synthase / 0.692
1tsy UMPThymidylate synthase / 0.679
1jmh UMPThymidylate synthase / 0.673
1tdu DURThymidylate synthase / 0.669
1ddu DDUThymidylate synthase / 0.665
4gcm NAPThioredoxin reductase 1.8.1.9 0.660
1bp6 UMPThymidylate synthase / 0.658
1tsv UMPThymidylate synthase / 0.658
4hs4 FMNChromate reductase / 0.658
2g89 UMPThymidylate synthase / 0.657
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.654
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.654
1q3g UDAUDP-N-acetylglucosamine 1-carboxyvinyltransferase / 0.653