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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qg2 CP6 Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.913
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.813
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.799
3qgt CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.764
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.754
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.748
4ddr MMVDihydrofolate reductase 1.5.1.3 0.741
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.736
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.727
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.723
3um8 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.711
3sgy 06WDihydrofolate reductase 1.5.1.3 0.678
3sa2 7DRDihydrofolate reductase / 0.669
1hfp MOTDihydrofolate reductase 1.5.1.3 0.665
3qly 55VUncharacterized protein / 0.664
1hfq MOTDihydrofolate reductase 1.5.1.3 0.662
3nxo D2BDihydrofolate reductase 1.5.1.3 0.657
3qlx QLRUncharacterized protein / 0.656
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.653
3sai 9DRDihydrofolate reductase / 0.650