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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qfb FAD Thioredoxin reductase 1, cytoplasmic 1.8.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.146
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.056
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.015
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 1.000
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.975
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.973
4la1 FADThioredoxin glutathione reductase / 0.970
2x8h FADThioredoxin glutathione reductase / 0.953
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.940
2x8g FADThioredoxin glutathione reductase / 0.937
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.932
4j57 FADThioredoxin reductase 2 1.8.1.9 0.930
2hqm FADGlutathione reductase 1.8.1.7 0.928
2tpr FADTrypanothione reductase 1.8.1.12 0.921
1ges FADGlutathione reductase 1.8.1.7 0.920
1get FADGlutathione reductase 1.8.1.7 0.908
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.907
1ger FADGlutathione reductase 1.8.1.7 0.905
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.902
2wba FADTrypanothione reductase 1.8.1.12 0.899
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.894
1fec FADTrypanothione reductase 1.8.1.12 0.893
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.884
2wow FADTrypanothione reductase / 0.880
1feb FADTrypanothione reductase 1.8.1.12 0.878
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.876
2v6o FADThioredoxin glutathione reductase / 0.875
2wp5 FADTrypanothione reductase / 0.874
1typ FADTrypanothione reductase 1.8.1.12 0.871
1bzl FADTrypanothione reductase 1.8.1.12 0.865
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.863
4nev FADTrypanothione reductase / 0.863
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.859
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.856
2eq7 FADDihydrolipoyl dehydrogenase / 0.854
2r9z FADGlutathione amide reductase / 0.854
2w0h FADTrypanothione reductase / 0.851
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.850
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.850
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.849
1zk7 FADMercuric reductase 1.16.1.1 0.849
2rab FADGlutathione amide reductase / 0.848
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.840
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.831
1geu FADGlutathione reductase 1.8.1.7 0.830
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.830
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.827
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.827
1tyt FADTrypanothione reductase 1.8.1.12 0.826
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.823
1zx9 FADMercuric reductase 1.16.1.1 0.821
2jk6 FADTrypanothione reductase / 0.821
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.819
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.814
2eq9 FADDihydrolipoyl dehydrogenase / 0.814
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.806
4j56 FADThioredoxin reductase 2 1.8.1.9 0.806
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.805
4dna FADProbable glutathione reductase / 0.805
4jq9 FADDihydrolipoyl dehydrogenase / 0.802
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.799
1fea FADTrypanothione reductase 1.8.1.12 0.797
1gxf FADTrypanothione reductase 1.8.1.12 0.797
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.794
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.790
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.790
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.787
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.776
1tdf FADThioredoxin reductase 1.8.1.9 0.773
4nte FADDepH / 0.773
2eq8 FADDihydrolipoyl dehydrogenase / 0.765
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.763
4b1b FADThioredoxin reductase 1.8.1.9 0.763
4ntc FADThioredoxin reductase gliT / 0.762
2eq6 FADDihydrolipoyl dehydrogenase / 0.760
1tde FADThioredoxin reductase 1.8.1.9 0.757
1nhp FADNADH peroxidase 1.11.1.1 0.756
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.756
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.750
2zbw FADFerredoxin--NADP reductase / 0.750
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.750
1b4v FADCholesterol oxidase 1.1.3.6 0.749
3urh FADDihydrolipoyl dehydrogenase / 0.748
4u2t FADCholesterol oxidase 1.1.3.6 0.747
3fbs FADOxidoreductase / 0.746
3cty FADProbable thioredoxin reductase / 0.744
2yqu FADDihydrolipoyl dehydrogenase / 0.742
1nhs FADNADH peroxidase 1.11.1.1 0.740
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.736
1trb FADThioredoxin reductase 1.8.1.9 0.735
4ccr FADThioredoxin reductase / 0.735
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.734
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.730
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.728
2qa1 FADPgaE / 0.726
4rek FADCholesterol oxidase 1.1.3.6 0.725
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.724
3gyi FADCholesterol oxidase 1.1.3.6 0.724
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.724
3lad FADDihydrolipoyl dehydrogenase / 0.724
4cbq FADThioredoxin reductase / 0.724
3ict FADCoenzyme A disulfide reductase / 0.722
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.721
1n4u FAECholesterol oxidase 1.1.3.6 0.720
2npx FADNADH peroxidase 1.11.1.1 0.720
3cnj FADCholesterol oxidase 1.1.3.6 0.720
2q0k FADThioredoxin reductase 1.8.1.9 0.719
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.718
1npx FADNADH peroxidase 1.11.1.1 0.718
2bac FADPutative aminooxidase / 0.716
4a65 FADThioredoxin reductase / 0.716
4gcm FADThioredoxin reductase 1.8.1.9 0.715
4bk3 FADProbable salicylate monooxygenase / 0.714
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.713
4a5l FADThioredoxin reductase / 0.713
4ccq FADThioredoxin reductase / 0.713
4hb9 FADUncharacterized protein / 0.712
4u2s FDACholesterol oxidase 1.1.3.6 0.712
1ijh FADCholesterol oxidase 1.1.3.6 0.710
1nhq FADNADH peroxidase 1.11.1.1 0.710
1onf FADGlutathione reductase 1.8.1.7 0.710
1mxt FAECholesterol oxidase 1.1.3.6 0.709
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.709
4xwr FADCholesterol oxidase 1.1.3.6 0.709
1n1p FADCholesterol oxidase 1.1.3.6 0.708
1n4v FADCholesterol oxidase 1.1.3.6 0.708
1n4w FADCholesterol oxidase 1.1.3.6 0.708
4up3 FADThioredoxin reductase / 0.708
4xxg FADCholesterol oxidase 1.1.3.6 0.708
2b9w FADPutative aminooxidase / 0.707
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.707
3ada NADSubunit alpha of sarocosine oxidase / 0.707
4jnq FDAThioredoxin reductase / 0.706
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.705
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.705
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
3cox FADCholesterol oxidase 1.1.3.6 0.704
1nhr FADNADH peroxidase 1.11.1.1 0.703
3b6d FAECholesterol oxidase 1.1.3.6 0.703
4j34 FADKynurenine 3-monooxygenase / 0.703
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.703
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.701
4j31 FADKynurenine 3-monooxygenase / 0.701
1gpe FADGlucose oxidase 1.1.3.4 0.700
3bg7 FADPyranose 2-oxidase / 0.700
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.699
3axb FADPutative oxidoreductase / 0.699
4cnk FADL-amino acid oxidase / 0.699
2b9y FADPutative aminooxidase / 0.697
5l3d FADLysine-specific histone demethylase 1A 1 0.697
3atq FDAConserved Archaeal protein / 0.695
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.695
2b9x FADPutative aminooxidase / 0.694
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.694
3ad9 NADSubunit alpha of sarocosine oxidase / 0.693
4gur FADLysine-specific histone demethylase 1B 1 0.692
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.692
2cvj FADThioredoxin reductase related protein / 0.690
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.690
4mok FADPyranose 2-oxidase / 0.688
4fwe FADLysine-specific histone demethylase 1B 1 0.687
3cgb FADCoenzyme A disulfide reductase / 0.686
3d8x FADThioredoxin reductase 1 1.8.1.9 0.686
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.686
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.685
4bjz FADProbable salicylate monooxygenase / 0.685
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.685
1cl0 FADThioredoxin reductase 1.8.1.9 0.684
1ojt FADDihydrolipoyl dehydrogenase / 0.684
2bab FADPutative aminooxidase / 0.684
4fwf FADLysine-specific histone demethylase 1B 1 0.684
4opu FDAConserved Archaeal protein / 0.684
4bk2 FADProbable salicylate monooxygenase / 0.683
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.683
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.683
2ba9 FADPutative aminooxidase / 0.682
3qj4 FADRenalase / 0.682
1rsg FADPolyamine oxidase FMS1 / 0.681
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.681
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.681
4opl FDAConserved Archaeal protein / 0.680
2whd FADThioredoxin reductase / 0.679
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.679
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.678
3ish FADThioredoxin reductase 1.8.1.9 0.678
4opg FDAConserved Archaeal protein / 0.678
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.677
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.677
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.677
4opi FDAConserved Archaeal protein / 0.677
2e1m FADL-glutamate oxidase / 0.676
3bi2 FADPolyamine oxidase FMS1 / 0.676
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.676
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.675
2igo FADPyranose 2-oxidase / 0.674
4mih FADPyranose 2-oxidase 1.1.3.10 0.674
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.673
2q0l FADThioredoxin reductase 1.8.1.9 0.673
3cgc FADCoenzyme A disulfide reductase / 0.673
4a99 FADTetX family tetracycline inactivation enzyme / 0.673
4fwj FADLysine-specific histone demethylase 1B 1 0.673
4guu FA9Lysine-specific histone demethylase 1B 1 0.673
3f8d FADNADH oxidase/thioredoxin reductase / 0.672
3pl8 FADPyranose 2-oxidase / 0.671
3r9u FADThioredoxin reductase / 0.671
4gus FADLysine-specific histone demethylase 1B 1 0.671
3itj FADThioredoxin reductase 1 1.8.1.9 0.670
4opc FDAConserved Archaeal protein / 0.670
1joa FADNADH peroxidase 1.11.1.1 0.669
3vqr FADPutative oxidoreductase / 0.669
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.668
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.668
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.667
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.667
4opt FDAConserved Archaeal protein / 0.667
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.666
3nlc FADUncharacterized protein / 0.666
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.665
1f8w FADNADH peroxidase 1.11.1.1 0.664
2q7v FADThioredoxin reductase / 0.663
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
2yg5 FADPutrescine oxidase / 0.662
3lsm SFDPyranose 2-oxidase / 0.662
1cbo FADCholesterol oxidase 1.1.3.6 0.661
4ynt FDAGlucose oxidase, putative / 0.661
2xdo FADTetX family tetracycline inactivation enzyme / 0.660
2ywl FADThioredoxin reductase related protein / 0.660
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.660
4jn9 FADDepH / 0.659
2ign FADPyranose 2-oxidase / 0.658
2uxx FAJLysine-specific histone demethylase 1A 1 0.658
4z24 FADPutative GMC-type oxidoreductase R135 1 0.658
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.657
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.656
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.656
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.655
3rha FDAPutrescine oxidase / 0.655
1ng4 FADGlycine oxidase 1.4.3.19 0.654
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.654
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.653
2yg6 FADPutrescine oxidase / 0.653
3cgd FADCoenzyme A disulfide reductase / 0.653
3cge FADCoenzyme A disulfide reductase / 0.653
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.653
1ryi FADGlycine oxidase 1.4.3.19 0.652
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.652
4i58 FADCyclohexylamine Oxidase / 0.652
4u8o FDAUDP-galactopyranose mutase / 0.652
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.651
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.651
4j33 FADKynurenine 3-monooxygenase / 0.651
4u8n FDAUDP-galactopyranose mutase / 0.651
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650
2jae FADL-amino acid oxidase / 0.650
3k4n FADPyranose 2-oxidase / 0.650
3lov FADProtoporphyrinogen oxidase / 0.650