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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qcs 3Q1 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.022
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.977
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.965
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.960
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.952
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.948
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.934
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.928
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.709
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.704
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.686
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.679
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.679
3nuu JOZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4nka 2K7Fibroblast growth factor receptor 1 / 0.673
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.672
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.669
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.668
3f88 3HTGlycogen synthase kinase-3 beta 2.7.11.26 0.667
4f64 0S8Fibroblast growth factor receptor 1 / 0.662
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.654
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.653
3rwp ABQ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651