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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3prs RIT Endothiapepsin 3.4.23.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3prs RITEndothiapepsin 3.4.23.22 1.410
1od1 0QSEndothiapepsin 3.4.23.22 0.767
1ppk IVVPenicillopepsin-1 3.4.23.20 0.764
2jjj 0QSEndothiapepsin 3.4.23.22 0.761
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.754
3q70 RITCandidapepsin-2 3.4.23.24 0.746
2jji 0QSEndothiapepsin 3.4.23.22 0.742
1gvw 0EMEndothiapepsin 3.4.23.22 0.734
1e81 M91Endothiapepsin 3.4.23.22 0.732
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.729
3tne RITCandidapepsin-1 3.4.23.24 0.718
3duy AFJBeta-secretase 1 3.4.23.46 0.696
2p3a 3TLPol protein / 0.695
1gvt 2ZSEndothiapepsin 3.4.23.22 0.681
3pww ROCEndothiapepsin 3.4.23.22 0.681
1rne C60Renin 3.4.23.15 0.668
2wed PP6Penicillopepsin-1 3.4.23.20 0.668
2p3c 3TLProtease / 0.667
3dv5 BAVBeta-secretase 1 3.4.23.46 0.666
2fxe DR7Gag-Pol polyprotein 3.4.23.16 0.663
3el1 DR7Gag-Pol polyprotein 3.4.23.16 0.663
3kfr 3TLGag-Pol polyprotein / 0.662
1hvs A77Gag-Pol polyprotein / 0.661
2web PP4Penicillopepsin-1 3.4.23.20 0.661
1hih C20Gag-Pol polyprotein / 0.660
1hvi A77Protease / 0.659
2iqg F2IBeta-secretase 1 3.4.23.46 0.655
3r4b 74TGag-Pol polyprotein / 0.655
4y35 F90Endothiapepsin 3.4.23.22 0.653
2f3e AXQBeta-secretase 1 3.4.23.46 0.651