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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pg3 DG7 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3pg3 DG7Mitogen-activated protein kinase 14 / 1.211
3lfe Z84Mitogen-activated protein kinase 14 / 0.865
3lff Z83Mitogen-activated protein kinase 14 / 0.831
3lfb Z87Mitogen-activated protein kinase 14 / 0.830
3hv6 R39Mitogen-activated protein kinase 14 / 0.826
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.750
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.744
3p5k P5KMitogen-activated protein kinase 14 / 0.741
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.741
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.739
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.737
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.720
3gcq 1BUMitogen-activated protein kinase 14 / 0.715
3hv5 R24Mitogen-activated protein kinase 14 / 0.711
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.709
3p7c P7CMitogen-activated protein kinase 14 / 0.705
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.696
3gi3 B10Mitogen-activated protein kinase 14 / 0.695
3lfc Z86Mitogen-activated protein kinase 14 / 0.695
3hv3 R49Mitogen-activated protein kinase 14 / 0.691
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.691
1w82 L10Mitogen-activated protein kinase 14 / 0.683
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.679
2yiw YIWMitogen-activated protein kinase 14 / 0.669
2yis YISMitogen-activated protein kinase 14 / 0.666
3uvr 06FMitogen-activated protein kinase 14 / 0.661
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.658
2puu G2GMitogen-activated protein kinase 14 / 0.656
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.652