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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pfi ADP Holliday junction ATP-dependent DNA helicase RuvB

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3pfi ADPHolliday junction ATP-dependent DNA helicase RuvB / 0.972
3zvm ADPBifunctional polynucleotide phosphatase/kinase 2.7.1.78 0.792
4gp6 ADPMetallophosphoesterase / 0.786
4jlo ADPAdenylate kinase / 0.777
4jl6 ADPAdenylate kinase / 0.776
1in5 ADPHolliday junction ATP-dependent DNA helicase RuvB / 0.773
1zcb GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.771
1l8q ADPChromosomal replication initiator protein DnaA / 0.768
5bn3 ADPV-type ATP synthase alpha chain / 0.765
5bn3 ADPNEQ263 / 0.765
1fnn ADPORC1-type DNA replication protein / 0.759
2fna ADPUncharacterized protein / 0.759
4ike ADPAdenylate kinase / 0.759
4jl5 ADPAdenylate kinase / 0.758
4qos ADPPsp operon transcriptional activator / 0.758
2jiz ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.756
4cf7 ADPAdenylate kinase / 0.756
1got GDPGuanine nucleotide-binding protein G(t) subunit alpha-1 / 0.755
3cx6 GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.754
3tqc ADPPantothenate kinase / 0.748
3r9i ADPSeptum site-determining protein MinD / 0.744
2jj2 ADPATP synthase subunit alpha, mitochondrial / 0.743
2jj2 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.743
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.742
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.742
1w0k ADPATP synthase subunit alpha, mitochondrial / 0.742
1w0k ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.742
2gks ADPProbable bifunctional SAT/APS kinase 2.7.1.25 0.742
1j7k ATPHolliday junction ATP-dependent DNA helicase RuvB / 0.740
3d8b ADPFidgetin-like protein 1 3.6.4 0.740
3kji ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.739
4jld ADPAdenylate kinase / 0.739
5aun ADPIron-sulfur cluster carrier protein / 0.739
2jj1 ADPATP synthase subunit alpha, mitochondrial / 0.738
2jj1 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.738
2ql6 ADPNicotinamide riboside kinase 1 / 0.738
4jky ADPAdenylate kinase / 0.737
3ews ADPATP-dependent RNA helicase DDX19B 3.6.4.13 0.735
2xae ADPKinesin-like protein KIF11 / 0.734
1h65 GDPTranslocase of chloroplast 34 3.6.5 0.733
3m0e ATPTranscriptional regulator (NtrC family) / 0.733
3tlx ADPAdenylate kinase 2 / 0.733
1ow3 GDPTransforming protein RhoA / 0.732
1w5t ANPORC1-type DNA replication protein 2 / 0.732
2rgx AP5Adenylate kinase / 0.732
1zio AP5Adenylate kinase / 0.731
4qbg AP5Adenylate kinase / 0.731
1wbb ADPDNA mismatch repair protein MutS / 0.729
2j0s ANPEukaryotic initiation factor 4A-III 3.6.4.13 0.729
3fmo ADPATP-dependent RNA helicase DDX19B 3.6.4.13 0.729
4lhv GDPRas-related protein Rab-8A / 0.728
1z0d GDPRas-related protein Rab-5C / 0.727
1e1q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.726
1sdm ADPKinesin heavy chain-like protein / 0.726
1z2a GDPRas-related protein Rab-23 / 0.725
2x2r ADPKinesin-like protein KIF11 / 0.724
3zia ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.724
1e79 ATPATP synthase subunit alpha, mitochondrial / 0.723
1e79 ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.723
2o8b ADPDNA mismatch repair protein Msh2 / 0.723
4hse ADPChaperone protein ClpB / 0.723
1cul GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.722
1gil GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.721
1w5s ADPORC1-type DNA replication protein 2 / 0.721
2c98 ADPPsp operon transcriptional activator / 0.721
5da9 AGSUncharacterized protein / 0.721
1ny5 ADPTranscriptional regulator (NtrC family) / 0.720
1xef ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.720
1e32 ADPTransitional endoplasmic reticulum ATPase 3.6.4.6 0.719
2xtz GSPGuanine nucleotide-binding protein alpha-1 subunit / 0.719
3cph GDPRas-related protein SEC4 / 0.719
4tla ADPCircadian clock protein kinase KaiC 2.7.11.1 0.718
5ftc ADPTPR domain protein / 0.718
5irn ADPNucleotide binding oligomerization domain containing 2 / 0.718
1azt GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.717
1xnj ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.715
1z0a GDPRas-related protein Rab-2A / 0.715
2v7q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.715
2zrj AGSProtein RecA / 0.715
3t1t GDPProbable gliding protein mglA / 0.715
3ieu GDPGTPase Era / 0.714
3q5d GDPAtlastin-1 3.6.5 0.714
3cob ADPKinesin heavy chain-like protein / 0.712
4obe GDPGTPase KRas / 0.712
5i67 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.712
1d5c GDPGTPase (Rab6) / 0.711
4dzz ADPPlasmid partitioning protein ParF / 0.711
4y0v GDPADP-ribosylation factor 1, putative / 0.711
4ylg GDPADP-ribosylation factor 1, putative / 0.711
4ymu ATPABC-type polar amino acid transport system, ATPase component / 0.711
1s3s ADPTransitional endoplasmic reticulum ATPase 3.6.4.6 0.710
4nh0 ATPESX secretion system protein EccC / 0.709
4pan GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.709
1gia GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.708
2xau ADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 3.6.4.13 0.708
5d3q GDPDynamin-1 3.6.5.5 0.708
2p2l GDPRas-related C3 botulinum toxin substrate 1 / 0.707
2uyi ADPKinesin-like protein KIF11 / 0.707
3a4l ANPL-seryl-tRNA(Sec) kinase 2.7.1.164 0.707
4iok ADPFormate--tetrahydrofolate ligase / 0.707
4pao GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.707
1ank ANPAdenylate kinase / 0.706
2r9v ATPATP synthase subunit alpha / 0.706
3cx8 GSPGuanine nucleotide-binding protein subunit alpha-13 / 0.706
3tif ADPUncharacterized ABC transporter ATP-binding protein MJ0796 / 0.706
4ldj GDPGTPase KRas / 0.706
1gp2 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.705
1z0f GDPRas-related protein Rab-14 / 0.705
2v7q ATPATP synthase subunit alpha, mitochondrial / 0.705
2v7q ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.705
3onw GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.705
3vhx GTPADP-ribosylation factor 6 / 0.705
4pjk ADPMyosin-2 heavy chain / 0.705
4r43 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.705
4tl9 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.705
4tle AGSCircadian clock protein kinase KaiC 2.7.11.1 0.705
4zca ADPKinesin-like protein KIF11 / 0.705
1yra GDPGPN-loop GTPase PAB0955 / 0.704
2ce7 ADPATP-dependent zinc metalloprotease FtsH / 0.704
2eck ADPAdenylate kinase / 0.704
2v1x ADPATP-dependent DNA helicase Q1 3.6.4.12 0.704
3zia ATPATP synthase subunit alpha, mitochondrial / 0.704
4lpk GDPGTPase KRas / 0.704
4xgu ADPPutative pachytene checkpoint protein 2 / 0.704
2ck3 ANPATP synthase subunit alpha, mitochondrial / 0.703
2ck3 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.703
1sq5 ADPPantothenate kinase 2.7.1.33 0.702
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.702
4hi0 GDPUrease accessory protein UreG / 0.702
4l9s GDPGTPase HRas / 0.702
1wdt GTPElongation factor G (EF-G-2) / 0.701
2j5x GSPADP-ribosylation factor 6 / 0.701
1bmf ANPATP synthase subunit alpha, mitochondrial / 0.700
1bmf ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.700
1x1r GDPRas-related protein M-Ras / 0.700
2cl6 CAGGTPase HRas / 0.700
2fe4 GDPRas-related protein Rab-6B / 0.700
2fl2 ADPKinesin-like protein KIF11 / 0.700
4q03 GDPGTPase KRas / 0.700
2qen ADPWalker-Type ATPase / 0.699
4ihq ADPConserved Archaeal protein / 0.699
4jsy GTPMetallophosphoesterase / 0.699
4ql3 GDPGTPase KRas / 0.699
5dac AGSUncharacterized protein / 0.699
2pg2 ADPKinesin-like protein KIF11 / 0.698
3x1w GDPRas-related protein Rap-1b / 0.698
1g16 GDPRas-related protein SEC4 / 0.697
2j0v GDPRac-like GTP-binding protein ARAC7 / 0.697
4yqf GDPSeptin-9 / 0.697
1bof GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.696
4b7b ADPKinesin-like protein KIF11 / 0.696
4dsu GDPGTPase KRas / 0.696
4g5q GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.696
4wa7 GDPGTPase KRas / 0.696
1g6o ADPCag alpha / 0.695
1zbd GTPRas-related protein Rab-3A / 0.695
1e4y AP5Adenylate kinase / 0.694
1z6t ADPApoptotic protease-activating factor 1 / 0.694
2c9c ATPPsp operon transcriptional activator / 0.694
3mjh GTPRas-related protein Rab-5A / 0.694
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.694
4mkf AP5Adenylate kinase / 0.694
4pfp ADPUnconventional myosin-VI / 0.694
1w7i ADPUnconventional myosin-Va / 0.693
4a1z ADPKinesin-like protein KIF11 / 0.693
4o2r GDPGTP-binding protein Rheb / 0.693
1mma ADPMyosin-2 heavy chain / 0.692
4asu ADPATP synthase subunit alpha, mitochondrial / 0.692
4ncl GDPEukaryotic translation initiation factor 5B / 0.692
4o2l GTPGTP-binding protein Rheb / 0.692
4pjj ADPUnconventional myosin-VI / 0.692
2c5l GTPGTPase HRas / 0.691
3dzd ADPTranscriptional regulator (NtrC family) / 0.691
3jvv ACPTwitching mobility protein / 0.691
4a51 ADPKinesin-like protein KIF11 / 0.691
4ag5 ADPType IV secretory pathway VirB4 components-like protein / 0.691
5hpy GDPTransforming protein RhoA / 0.691
1w1w AGSStructural maintenance of chromosomes protein 1 / 0.690
2c9o ADPRuvB-like 1 3.6.4.12 0.690
4c2u ANPDNA helicase / 0.690
4a28 ADPKinesin-like protein KIF11 / 0.689
4d81 ADPAAA ATPase, central domain protein / 0.689
3l9h ADPKinesin-like protein KIF11 / 0.688
3vtk ADPThymidine kinase / 0.688
4idn GNPAtlastin-1 3.6.5 0.688
4mkh AP5Adenylate kinase / 0.688
3bos CDPRegulatory inactivation of DnaA Hda protein / 0.687
3l1c ADPProtein claret segregational / 0.687
4bzq ADPBifunctional enzyme CysN/CysC 2.7.1.25 0.687
4l8g GDPGTPase KRas / 0.687
2ce2 GDPGTPase HRas / 0.686
2l0x GDPGTP-binding protein Rheb / 0.686
2g0n GDPRas-related C3 botulinum toxin substrate 3 / 0.685
2g1q ADPKinesin-like protein KIF11 / 0.685
2gm1 ADPKinesin-like protein KIF11 / 0.685
2zfi ADPKinesin-like protein KIF1A / 0.685
3hu3 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.685
4e07 ACPPlasmid partitioning protein ParF / 0.685
4itr GDPCell division control protein 42 homolog / 0.685
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.684
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.684
2aky AP5Adenylate kinase / 0.684
2dr3 ADPUPF0273 protein PH0284 / 0.684
4epw GDPGTPase KRas / 0.684
4xvq GNPGTPase HRas / 0.684
5ftf ADPTPR domain protein / 0.684
3c41 ANPAmino acid ABC transporter / 0.683
4g01 GDPRas-related protein RABF2b / 0.683
1mmg AGSMyosin-2 heavy chain / 0.682
1nly AGSCag alpha / 0.681
1yrs ADPKinesin-like protein KIF11 / 0.681
3pcr GTPADP-ribosylation factor 6 / 0.681
4ww4 ADPRuvB-like helicase / 0.681
3mle ADPATP-dependent dethiobiotin synthetase BioD 6.3.3.3 0.680
3tkl GTPRas-related protein Rab-1A / 0.680
4idp GNPAtlastin-1 3.6.5 0.680
4tld AGSCircadian clock protein kinase KaiC 2.7.11.1 0.680
2bbw GP5Adenylate kinase 4, mitochondrial / 0.679
3ref GDPRho family GTPase / 0.679
4ap0 ADPKinesin-like protein KIF11 / 0.679
2x7e ADPKinesin-like protein KIF11 / 0.678
3bb3 GDPTranslocase of chloroplast 33, chloroplastic 3.6.5 0.678
3ea5 GDPGTP-binding nuclear protein Ran / 0.678
3moh GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.678
1i4l GDPRas-related C3 botulinum toxin substrate 1 / 0.677
1xd9 ADPNitrogenase iron protein 1 1.18.6.1 0.677
3k1j ADPATP-dependent protease Lon / 0.677
4dxa GSPRas-related protein Rap-1b / 0.677
4ww0 ADPATP-dependent zinc metalloprotease FtsH / 0.677
2db3 ANPATP-dependent RNA helicase vasa, isoform A 3.6.4.13 0.676
5fl3 ADPPili retraction protein PilT / 0.676
2ffq GSPRas-related protein Rab-6B / 0.675
2qaj AP5Adenylate kinase / 0.675
2qf2 GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.674
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.674
4cvl ACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.674
4wou GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.674
1njf ADPDNA polymerase III subunit tau 2.7.7.7 0.673
3rab GNPRas-related protein Rab-3A / 0.673
1ht2 ADPATP-dependent protease ATPase subunit HslU / 0.672
1w5t ADPORC1-type DNA replication protein 2 / 0.672
2q3f GNPRas-related GTP-binding protein D / 0.672
2y65 ADPKinesin heavy chain / 0.672
4goj GNPADP-ribosylation factor-like protein 3 / 0.672
5cyo GDPSeptin-9 / 0.672
1r0z ATPCystic fibrosis transmembrane conductance regulator / 0.671
2qtv GNPSmall COPII coat GTPase SAR1 3.6.5 0.671
5di3 GNPADP-ribosylation factor-like protein 3 / 0.671
1jx2 ADPMyosin-2 heavy chain / 0.670
1sxj AGSReplication factor C subunit 1 / 0.670
1xtr GNPGTP-binding protein Rheb / 0.670
2hld ANPATP synthase subunit alpha, mitochondrial / 0.670
2hld ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.670
3a6p GTPGTP-binding nuclear protein Ran / 0.670
4yer ADPAntibiotic ABC transporter, ATP-binding protein, putative / 0.670
1e1q ANPATP synthase subunit alpha, mitochondrial / 0.668
1e1q ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.668
3oes GNPGTPase RhebL1 / 0.668
4dlz GNPGTPase HRas / 0.668
1aq2 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.667
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.666
3adc ANPL-seryl-tRNA(Sec) kinase 2.7.1.164 0.666
3ftq GNPSeptin-2 / 0.666
4wpu GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.666
1tu3 GNPRas-related protein Rab-5A / 0.665
2w2v GTPRas-related C3 botulinum toxin substrate 2 / 0.665
3bc1 GNPRas-related protein Rab-27A / 0.665
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.665
3myk ANPMyosin-2 heavy chain / 0.665
4lv6 GDPGTPase KRas / 0.665
2bif ANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 2.7.1.105 0.664
3k3b ADPKinesin-like protein KIF11 / 0.664
4q02 GDPGTPase KRas / 0.664
4tq9 GDPGTPase KRas / 0.664
1ibr GNPGTP-binding nuclear protein Ran / 0.663
3kko GNPRas-related protein M-Ras / 0.663
3zfd ANPChromosome-associated kinesin KIF4 / 0.663
4o3m ADPBloom syndrome protein 3.6.4.12 0.662
1b7t ADPMyosin heavy chain, striated muscle / 0.660
1oix GDPRas-related protein Rab-11A / 0.660
3zl8 ADPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.660
3nbx ADPATPase RavA 3.6.3 0.659
1n6l GTPRas-related protein Rab-5A / 0.658
2ic5 GDPRas-related C3 botulinum toxin substrate 3 / 0.658
3uk6 ADPRuvB-like 2 3.6.4.12 0.658
1am4 GNPCell division control protein 42 homolog / 0.657
1svl ADPLarge T antigen 3.6.4 0.657
2bme GNPRas-related protein Rab-4A / 0.657
4dso GSPGTPase KRas / 0.657
4w5j AP5Adenylate kinase / 0.657
5bn4 ANPV-type ATP synthase alpha chain / 0.657
3hu2 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.656
4hdq GNPRas-related protein Rap-1b / 0.656
1xkv ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.655
1y3a GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.655
2jlr ANPGenome polyprotein 3.4.21.91 0.655
2rge GNPGTPase HRas / 0.655
2zro ADPProtein RecA / 0.655
3k8y GNPGTPase HRas / 0.655
4cym GCPRas-related protein Rab-32 / 0.655
4dlt GNPGTPase HRas / 0.655
4hdo GNPRas-related protein Rap-1b / 0.655
4l9w GNPGTPase HRas / 0.655
4luc GDPGTPase KRas / 0.655
4pk4 ADPUnconventional myosin-VI / 0.655
1im2 ADPATP-dependent protease ATPase subunit HslU / 0.654
1s3g AP5Adenylate kinase / 0.654
2bc9 GNPGuanylate-binding protein 1 / 0.654
2rgc GNPGTPase HRas / 0.654
2vf7 ADPUvrABC system protein A / 0.654
3oiw GNPGTPase HRas / 0.654
4ohx ADPProtein clpf-1 / 0.654
1cxz GSPTransforming protein RhoA / 0.653
2q2z ADPKinesin-like protein KIF11 / 0.653
4dlx GNPGTPase HRas / 0.653
4iei ADPGene 2 protein / 0.653
4k81 GTPGTPase HRas / 0.652
1p9w ANPType II secretion system protein E / 0.651
4js0 GNPCell division control protein 42 homolog / 0.651
1rrg GDPADP-ribosylation factor 1 / 0.650
3lbh GNPGTPase HRas / 0.650