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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p74 FMN Pentaerythritol tetranitrate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3p74 FMNPentaerythritol tetranitrate reductase / 1.302
3p62 FMNPentaerythritol tetranitrate reductase / 1.293
1vyr FMNPentaerythritol tetranitrate reductase / 1.171
3f03 FMNPentaerythritol tetranitrate reductase / 1.161
3p82 FMNPentaerythritol tetranitrate reductase / 1.134
3p8j FMNPentaerythritol tetranitrate reductase / 1.129
1h51 FMNPentaerythritol tetranitrate reductase / 1.120
2abb FMNPentaerythritol tetranitrate reductase / 1.119
1h50 FMNPentaerythritol tetranitrate reductase / 1.116
3p67 FMNPentaerythritol tetranitrate reductase / 1.114
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.108
3p8i FMNPentaerythritol tetranitrate reductase / 1.103
3p84 FMNPentaerythritol tetranitrate reductase / 1.068
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.057
1h63 FMNPentaerythritol tetranitrate reductase / 1.047
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 1.038
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 1.032
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 1.026
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.020
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.989
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.988
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.980
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.979
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.976
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.962
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.955
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.953
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.947
4tmc FMNOld yellow enzyme / 0.942
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.936
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.933
3tjl FMNNADPH dehydrogenase / 0.930
4m5p FMNNADPH dehydrogenase / 0.929
4e2b FMNDehydrogenase / 0.926
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.917
4df2 FMNNADPH dehydrogenase / 0.917
1gwj FMNMorphinone reductase / 0.913
4e2d FMNDehydrogenase / 0.913
4tmb FMNOld yellow enzyme / 0.909
3gka FMNN-ethylmaleimide reductase / 0.897
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.891
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.888
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.878
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.864
4uth FMNXenobiotic reductase / 0.856
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.854
3l5l FMNXenobiotic reductase / 0.845
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.840
4utl FNRXenobiotic reductase / 0.839
4utm FNRXenobiotic reductase / 0.838
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.837
3l67 FMNXenobiotic reductase / 0.832
5cpm FNRNADH:flavin oxidoreductase / 0.831
4jic FMNGTN Reductase / 0.822
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.819
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.816
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.812
4utk FNRXenobiotic reductase / 0.809
4yco FMNtRNA-dihydrouridine(16) synthase / 0.806
3atz FMNProstaglandin F2a synthase / 0.804
3n14 FMNXenobiotic reductase / 0.796
2zfa FMNLactate oxidase / 0.793
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.793
3n19 FNRXenobiotic reductase / 0.785
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.780
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.777
1z48 FMNNADPH dehydrogenase / 0.776
5ebu FMNLactate oxidase / 0.770
2du2 FMNLactate oxidase / 0.769
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.765
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.764
3hf3 FMNChromate reductase / 0.763
1z44 FMNNADPH dehydrogenase / 0.757
1z41 FMNNADPH dehydrogenase / 0.754
2e77 FMNLactate oxidase / 0.750
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.744
2z6i FMN2-nitropropane dioxygenase / 0.742
2j6x FMNLactate oxidase / 0.740
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.737
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.732
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.731
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.730
1vhn FMNtRNA-dihydrouridine synthase / 0.724
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.720
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.718
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.716
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.716
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.715
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.714
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.713
3gr8 FMNNADPH dehydrogenase / 0.710
4yl2 FMNLactate oxidase / 0.706
2gjl FMNNitronate monooxygenase 1.13.12.16 0.705
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.705
2oz0 FMNCytochrome b2, mitochondrial 1.1.2.3 0.698
3oix FMNDihydroorotate dehydrogenase / 0.698
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.697
2h8x FMNXenA / 0.696
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.695
3bw4 FMNPutative 2-nitropropane dioxygenase / 0.695
3b03 VNRIsopentenyl-diphosphate delta-isomerase / 0.693
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.687
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.684
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.680
2b3d FADModulator of drug activity B / 0.680
1n9l FMNPutative blue light receptor / 0.679
4cw5 FMNDfnA / 0.678
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.676
3w77 FMNFMN-dependent NADH-azoreductase / 0.676
3aty FMNProstaglandin F2a synthase / 0.672
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.668
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.666
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.666
4z38 FMNMlnA / 0.665
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.664
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.663
3esz FMNFlavodoxin / 0.663
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.663
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.661
4bca FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.661
4ejm NAPPutative zinc-binding dehydrogenase / 0.661
1t5b FMNFMN-dependent NADH-azoreductase / 0.660
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.659
2jk6 FADTrypanothione reductase / 0.658
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.658
4yus FMNFamily 3 adenylate cyclase / 0.658
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.655
3bgx TMPThymidylate synthase / 0.654
3gfz FMNUncharacterized protein / 0.654
3zy3 GDPGDP-fucose protein O-fucosyltransferase 1 2.4.1.221 0.654
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.651
4qai FMNNADPH dehydrogenase / 0.651
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.650