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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3oct 1N1 Tyrosine-protein kinase BTK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 1.112
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.890
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.876
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.866
3lfa 1N1Mitogen-activated protein kinase 14 / 0.845
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.834
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.783
4kip 1R9Mitogen-activated protein kinase 14 / 0.760
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.710
3itz P66Mitogen-activated protein kinase 14 / 0.707
3fsk RO6Mitogen-activated protein kinase 14 / 0.695
4eh6 0ONMitogen-activated protein kinase 14 / 0.681
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.672
4f65 0S9Fibroblast growth factor receptor 1 / 0.671
2zm4 KSMTyrosine-protein kinase Lck 2.7.10.2 0.667
3fmn 530Mitogen-activated protein kinase 14 / 0.667
3mvm 39PMitogen-activated protein kinase 14 / 0.662
3cem AVDGlycogen phosphorylase, liver form 2.4.1.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4kin 1M8Mitogen-activated protein kinase 14 / 0.659
4nk9 2K5Fibroblast growth factor receptor 1 / 0.654
2rg6 287Mitogen-activated protein kinase 14 / 0.653
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.651
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.651
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.650