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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3o3r NAP Aldose reductase-related protein 1 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.545
3q67 NAPAldose reductase 1.1.1.21 1.326
2acs NAPAldose reductase 1.1.1.21 1.250
2iq0 NAPAldose reductase 1.1.1.21 1.233
3v36 NAPAldose reductase 1.1.1.21 1.231
2pf8 NDPAldose reductase 1.1.1.21 1.218
2acu NAPAldose reductase 1.1.1.21 1.216
2pev NDPAldose reductase 1.1.1.21 1.214
2acq NAPAldose reductase 1.1.1.21 1.204
1ads NAPAldose reductase 1.1.1.21 1.203
3q65 NAPAldose reductase 1.1.1.21 1.196
1x98 NAPAldose reductase 1.1.1.21 1.179
1x96 NAPAldose reductase 1.1.1.21 1.170
1ef3 NAPAldose reductase 1.1.1.21 1.147
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.126
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.122
1z8a NAPAldose reductase 1.1.1.21 1.109
2bgs NDPAldose reductase 1.1.1.21 1.105
2pfh NDPAldose reductase 1.1.1.21 1.100
1ah4 NAPAldose reductase 1.1.1.21 1.095
2j8t NAPAldose reductase 1.1.1.21 1.094
3h7r NAPAldo-keto reductase family 4 member C8 / 1.092
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.087
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.075
4pmj NAPPutative oxidoreductase / 1.074
1az2 NAPAldose reductase 1.1.1.21 1.070
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.069
3qkz NAPAldose reductase-related protein 1 1.1.1.21 1.046
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.038
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.037
5c7h NDPPutative oxidoreductase / 1.037
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 1.030
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 1.020
2vdg NDPAldose reductase 1.1.1.21 1.011
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.982
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.973
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.965
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.951
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.939
1s1p NAPAldo-keto reductase family 1 member C3 / 0.937
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.927
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.924
3wcz NAPAldo-keto reductase AKR2E4 / 0.924
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.905
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.900
4g5d NDPProstaglandin F synthase 1.1.1.188 0.892
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.887
4jtq NAPAldo-keto reductase family 1 member C2 / 0.853
1zgd NAPChalcone reductase / 0.835
1s1r NAPAldo-keto reductase family 1 member C3 / 0.831
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.818
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.816
2hdj NDPAldo-keto reductase family 1 member C2 / 0.810
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.781
4l1x NAPAldo-keto reductase family 1 member C2 / 0.781
1c9w NAPAldose reductase-related protein 2 / 0.772
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.756
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.748
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.723
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.719
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.714
1og6 NAPOxidoreductase YdhF 1 0.711
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.710
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.710
3ln3 NADAldo-keto reductase family 1 member C13 / 0.710
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.700
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.690
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.676
4jtd NAPVoltage-gated potassium channel subunit beta-2 / 0.669
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.664