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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nxo D2B Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nxo D2BDihydrofolate reductase 1.5.1.3 0.932
3k45 51PDihydrofolate reductase 1.5.1.3 0.741
3nxt D2EDihydrofolate reductase 1.5.1.3 0.723
3gyf 51PDihydrofolate reductase 1.5.1.3 0.715
2w3m FOLDihydrofolate reductase 1.5.1.3 0.686
4kak 06UDihydrofolate reductase 1.5.1.3 0.686
4m6l 21VDihydrofolate reductase 1.5.1.3 0.673
3k47 D09Dihydrofolate reductase 1.5.1.3 0.669
3qlz QLZUncharacterized protein / 0.668
4keb FOLDihydrofolate reductase 1.5.1.3 0.666
1hfq MOTDihydrofolate reductase 1.5.1.3 0.663
3n0h TOPDihydrofolate reductase 1.5.1.3 0.662
4ddr MMVDihydrofolate reductase 1.5.1.3 0.662
3s3v TOPDihydrofolate reductase 1.5.1.3 0.659
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.657
3l3r OAGDihydrofolate reductase 1.5.1.3 0.656
1hfp MOTDihydrofolate reductase 1.5.1.3 0.655
1dhf FOLDihydrofolate reductase 1.5.1.3 0.653
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.653
3cse N22Uncharacterized protein / 0.653
1dls MTXDihydrofolate reductase 1.5.1.3 0.651