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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nwb 659 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nwb 659Catechol O-methyltransferase 2.1.1.6 1.280
3nwe 662Catechol O-methyltransferase 2.1.1.6 1.181
3hvi 619Catechol O-methyltransferase 2.1.1.6 1.165
3hvk 719Catechol O-methyltransferase 2.1.1.6 1.159
3r6t LU1Catechol O-methyltransferase 2.1.1.6 1.054
3nw9 637Catechol O-methyltransferase 2.1.1.6 1.005
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.942
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.888
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.864
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.853
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.849
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.812
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.740
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.724
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.724
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.711
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.701
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.692
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.690
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.686
1g60 SAMModification methylase MboII 2.1.1.72 0.672
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.662
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.662
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.659
3sgl SAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.655
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.652
2nxe SAMRibosomal protein L11 methyltransferase 2.1.1 0.651
2cdu ADPNADH oxidase / 0.650
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.650