sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 1.276 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 1.095 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 1.032 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 1.020 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 1.001 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.997 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.989 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.980 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.971 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.961 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.961 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.943 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.939 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.935 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.935 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.926 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.923 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.920 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.917 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.916 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.913 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.912 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.912 | |
| 4kwh | NAP | Reductase homolog | / | 0.908 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.899 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.897 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.896 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.893 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.890 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.887 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.887 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.880 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.879 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.879 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.878 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.878 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.875 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.873 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.873 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.872 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.872 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.867 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.867 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.864 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.860 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.860 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.860 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.859 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.857 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.855 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.855 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.853 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.852 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.851 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.850 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.850 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.849 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.848 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.848 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.848 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.846 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.846 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.846 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.846 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.845 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.845 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.845 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.845 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.844 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.843 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.843 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.843 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.842 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.840 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.840 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.838 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.836 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.836 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.835 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.831 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.831 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.830 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.830 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.828 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.827 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.827 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.826 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.825 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.825 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.823 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.822 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.822 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.822 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.821 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.820 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.819 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.819 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.819 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.818 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.817 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.817 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.816 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.815 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.815 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.811 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.811 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.810 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.810 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.809 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.809 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.806 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.806 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.801 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.800 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.800 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.797 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.792 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.792 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.791 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.790 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.790 | |
| 4u7w | NDP | MxaA | / | 0.790 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.789 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.786 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.786 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.786 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.786 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.786 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.785 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.785 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.785 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.784 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.784 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.782 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.780 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.780 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.777 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.777 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.777 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.776 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.775 | |
| 4qec | NAP | ElxO | / | 0.774 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.773 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.770 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.767 | |
| 4qed | NAP | ElxO | / | 0.766 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.763 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.762 | |
| 3bmo | NAP | Pteridine reductase | / | 0.762 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.761 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.760 | |
| 4clo | NAP | Pteridine reductase | / | 0.759 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.758 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.755 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.755 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.754 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.752 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.750 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.750 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.750 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.750 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.749 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.749 | |
| 4hxy | NDP | Plm1 | / | 0.749 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.748 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.747 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.747 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.744 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.744 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.743 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.742 | |
| 1sny | NAP | LD36273p | / | 0.739 | |
| 3mje | NDP | AmphB | / | 0.739 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.738 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.736 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.736 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.735 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.734 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.734 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.734 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.734 | |
| 1iy8 | NAD | Levodione reductase | / | 0.733 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.732 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.731 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.729 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.729 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.729 | |
| 3sju | NDP | Keto reductase | / | 0.728 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.727 | |
| 3uce | NDP | Dehydrogenase | / | 0.727 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.727 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.726 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.725 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.725 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.725 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.723 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.723 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.723 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.722 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.722 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.722 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.721 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.720 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.720 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.719 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.719 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.719 | |
| 5d2e | NAP | MlnE | / | 0.719 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.715 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.715 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.715 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.713 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.712 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.710 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.710 | |
| 4l4x | NDP | AmphI | / | 0.710 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.708 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.708 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.706 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.704 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.703 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.703 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.702 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.702 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.702 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.702 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.702 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.700 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.700 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.699 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.696 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.695 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.694 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.693 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.693 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.693 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.690 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.689 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.689 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.687 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.686 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.685 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.685 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.685 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.685 | |
| 4c4o | NAD | SADH | / | 0.683 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.683 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.682 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.681 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.681 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.681 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.679 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.679 | |
| 4iv8 | SAM | Phosphoethanolamine N-methyltransferase,putative | / | 0.678 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.678 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.677 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.676 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.675 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.674 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.673 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.673 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.672 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.672 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.672 | |
| 4y1b | NAP | AntE | / | 0.672 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.671 | |
| 2p9e | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.671 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.670 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.670 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.669 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.669 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.668 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.668 | |
| 3pdu | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.666 | |
| 4kvz | SAH | PtnL protein | / | 0.666 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.666 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.664 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.664 | |
| 1sqf | SAM | Ribosomal RNA small subunit methyltransferase B | 2.1.1.176 | 0.663 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.663 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.663 | |
| 1wg8 | SAM | Ribosomal RNA small subunit methyltransferase H | / | 0.662 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.662 | |
| 2okc | SAM | Probable type I restriction enzyme BthVORF4518P M protein | 2.1.1.72 | 0.661 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.661 | |
| 1ri3 | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.660 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.659 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.659 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.659 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.658 | |
| 3k30 | ADP | Histamine dehydrogenase | / | 0.658 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.658 | |
| 4y0k | NAP | AntE | / | 0.658 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.657 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.657 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.657 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.656 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.656 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.656 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.655 | |
| 3q2k | NAI | Probable oxidoreductase | / | 0.655 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.654 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.653 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.653 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.653 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.653 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.652 | |
| 4yuv | S4M | Spermidine synthase, putative | / | 0.652 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.651 | |
| 3sr4 | TT8 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.651 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.651 | |
| 1djn | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.650 | |
| 1o94 | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.650 | |
| 3c96 | FAD | Flavin-containing monooxygenase | / | 0.650 |