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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nsz ANP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.994
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.874
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.814
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.809
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.787
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.779
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.778
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.777
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.771
2pun ACPMethylthioribose kinase 2.7.1.100 0.763
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.761
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.761
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.757
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.750
2pul ACPMethylthioribose kinase 2.7.1.100 0.747
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.744
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.742
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.739
3c50 ADPRhodopsin kinase / 0.739
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.738
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.738
3qc9 ADPRhodopsin kinase / 0.738
3t8o ATPRhodopsin kinase / 0.738
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.737
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.733
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
2pup ADPMethylthioribose kinase 2.7.1.100 0.731
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.731
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.729
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.728
4qny ANPMitogen activated protein kinase, putative / 0.728
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.728
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.723
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.722
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.721
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.721
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.721
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.720
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.720
5byl GCPBifunctional AAC/APH 2.3.1 0.720
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.719
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.719
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.719
5dt3 ATPAurora kinase A 2.7.11.1 0.719
1m0w ANPGlutathione synthetase 6.3.2.3 0.718
2dwb ANPAurora kinase A 2.7.11.1 0.717
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
2zdg ADPD-alanine--D-alanine ligase / 0.716
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.715
4gyi ADPUncharacterized protein / 0.715
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.713
4ceg ADPAurora kinase A 2.7.11.1 0.713
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.713
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.712
5iqb GNPBifunctional AAC/APH 2.3.1 0.712
2pui ADPMethylthioribose kinase 2.7.1.100 0.711
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.710
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.710
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.709
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.709
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.709
5dr2 ATPAurora kinase A 2.7.11.1 0.709
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.708
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.707
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.707
1mq4 ADPAurora kinase A 2.7.11.1 0.706
3c4w ATPRhodopsin kinase / 0.706
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.704
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
5dn3 ATPAurora kinase A 2.7.11.1 0.703
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.702
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.702
2py3 ACPFibroblast growth factor receptor 2 / 0.702
3c4z ADPRhodopsin kinase / 0.702
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.702
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.701
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.701
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.701
3ort AGSSerine/threonine protein kinase / 0.701
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.701
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.700
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.700
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.699
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.698
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.697
1ol6 ATPAurora kinase A 2.7.11.1 0.697
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.697
5ce3 ADPProtein kinase YopO / 0.696
3a8w ATPProtein kinase C iota type 2.7.11.13 0.695
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.694
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.694
4xlv ACPInsulin receptor 2.7.10.1 0.694
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.693
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.692
5drd ATPAurora kinase A 2.7.11.1 0.692
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.691
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.691
4dee ADPAurora kinase A 2.7.11.1 0.691
2olc ADPMethylthioribose kinase 2.7.1.100 0.690
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4utd ACPAurora kinase A 2.7.11.1 0.690
1dv2 ATPBiotin carboxylase 6.3.4.14 0.689
2pz5 ACPFibroblast growth factor receptor 2 / 0.689
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.688
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.686
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.686
5iqh GNPBifunctional AAC/APH 2.3.1 0.686
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.685
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.685
5iqa GNPBifunctional AAC/APH 2.3.1 0.685
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.684
3ori AGSSerine/threonine protein kinase / 0.683
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.683
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4q5h ANPProtein kinase OspG 2.7 0.683
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.683
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.683
3oro AGSSerine/threonine protein kinase / 0.682
4o4d ATPKinase / 0.682
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.680
1pk8 ATPSynapsin-1 / 0.679
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.679
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.677
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.677
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.676
4bn1 ADPAurora kinase A 2.7.11.1 0.676
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.675
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.675
4o4e ATPKinase / 0.675
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.674
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.673
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.673
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.673
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.673
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.673
5iqe GNPBifunctional AAC/APH 2.3.1 0.673
3orp AGSSerine/threonine protein kinase / 0.672
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.671
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.671
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.670
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.670
4ysj ADPCalmodulin-like domain protein kinase / 0.670
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.669
4ffr ATPUncharacterized protein / 0.669
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.669
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.668
2pzp ACPFibroblast growth factor receptor 2 / 0.666
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.666
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3nie ANPMitogen-activated protein kinase / 0.664
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.664
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.664
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3cly ACPFibroblast growth factor receptor 2 / 0.663
4o4f ATPKinase / 0.663
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.662
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.661
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.661
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.660
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.660
5dos ATPAurora kinase A 2.7.11.1 0.659
1u54 ACPActivated CDC42 kinase 1 / 0.657
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.657
3orm AGSSerine/threonine protein kinase / 0.657
2yaa ATPDeath-associated protein kinase 2 / 0.656
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.655
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.655
3llt ANPProtein serine/threonine kinase-1 / 0.655
3q5i ANPProtein kinase, putative / 0.655
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.655
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
5iqd GNPBifunctional AAC/APH 2.3.1 0.653
1cm8 ANPMitogen-activated protein kinase 12 / 0.652
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.652
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.652
4o1p ANPRibonuclease L / 0.652
3hzi ATPSerine/threonine-protein kinase toxin HipA / 0.651
1i44 ACPInsulin receptor 2.7.10.1 0.650
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.650