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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nnx EDD Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nnx EDDMitogen-activated protein kinase 14 / 1.269
3nnw EDDMitogen-activated protein kinase 14 / 1.062
2yiw YIWMitogen-activated protein kinase 14 / 0.946
3nnu EDBMitogen-activated protein kinase 14 / 0.945
3hv7 1AUMitogen-activated protein kinase 14 / 0.911
3uvr 06FMitogen-activated protein kinase 14 / 0.906
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.890
1w82 L10Mitogen-activated protein kinase 14 / 0.885
3p7c P7CMitogen-activated protein kinase 14 / 0.880
2yis YISMitogen-activated protein kinase 14 / 0.864
3gcq 1BUMitogen-activated protein kinase 14 / 0.858
3hv3 R49Mitogen-activated protein kinase 14 / 0.857
3p7a P7AMitogen-activated protein kinase 14 / 0.838
3hv6 R39Mitogen-activated protein kinase 14 / 0.831
2puu G2GMitogen-activated protein kinase 14 / 0.824
3hv4 L51Mitogen-activated protein kinase 14 / 0.785
1kv2 B96Mitogen-activated protein kinase 14 / 0.780
3gi3 B10Mitogen-activated protein kinase 14 / 0.777
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.777
1kv1 BMUMitogen-activated protein kinase 14 / 0.763
3gcv SS6Mitogen-activated protein kinase 14 / 0.759
3gcu R48Mitogen-activated protein kinase 14 / 0.747
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.744
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.742
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.742
3o8u BMUMitogen-activated protein kinase 14 / 0.740
3hv5 R24Mitogen-activated protein kinase 14 / 0.732
3o8t BMUMitogen-activated protein kinase 14 / 0.715
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.713
1wbv LI3Mitogen-activated protein kinase 14 / 0.710
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.707
3lfe Z84Mitogen-activated protein kinase 14 / 0.705
3uvq FS8Mitogen-activated protein kinase 14 / 0.705
3nww 3NWMitogen-activated protein kinase 14 / 0.694
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.685
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.684
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.682
3oc1 BMUMitogen-activated protein kinase 14 / 0.679
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.677
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.672
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.665
3lff Z83Mitogen-activated protein kinase 14 / 0.663
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.662
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.661
5j3w FMNSensory box protein / 0.661
3k3j F4CMitogen-activated protein kinase 14 / 0.657
1w83 L11Mitogen-activated protein kinase 14 / 0.656
3akn 11DFatty acid-binding protein, intestinal / 0.656
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.655
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.655