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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nnw EDD Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nnw EDDMitogen-activated protein kinase 14 / 1.171
3nnx EDDMitogen-activated protein kinase 14 / 1.062
3nnu EDBMitogen-activated protein kinase 14 / 0.957
2yis YISMitogen-activated protein kinase 14 / 0.889
3uvr 06FMitogen-activated protein kinase 14 / 0.878
2yiw YIWMitogen-activated protein kinase 14 / 0.874
3hv7 1AUMitogen-activated protein kinase 14 / 0.871
1w82 L10Mitogen-activated protein kinase 14 / 0.866
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.831
3hv3 R49Mitogen-activated protein kinase 14 / 0.825
3gcq 1BUMitogen-activated protein kinase 14 / 0.812
3p7c P7CMitogen-activated protein kinase 14 / 0.809
3p5k P5KMitogen-activated protein kinase 14 / 0.796
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.780
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.768
3gcu R48Mitogen-activated protein kinase 14 / 0.766
3hv6 R39Mitogen-activated protein kinase 14 / 0.757
3p7b P7BMitogen-activated protein kinase 14 / 0.753
3gcv SS6Mitogen-activated protein kinase 14 / 0.747
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.743
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.735
3hv5 R24Mitogen-activated protein kinase 14 / 0.733
3hv4 L51Mitogen-activated protein kinase 14 / 0.731
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.719
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.715
3oc1 BMUMitogen-activated protein kinase 14 / 0.702
2puu G2GMitogen-activated protein kinase 14 / 0.685
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.685
3o8t BMUMitogen-activated protein kinase 14 / 0.683
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.683
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.676
3o8u BMUMitogen-activated protein kinase 14 / 0.674
3lff Z83Mitogen-activated protein kinase 14 / 0.673
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.672
1w83 L11Mitogen-activated protein kinase 14 / 0.671
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.671
3lfe Z84Mitogen-activated protein kinase 14 / 0.668
3e92 G6AMitogen-activated protein kinase 14 / 0.663
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.663
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.663
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.660
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.659
3gi3 B10Mitogen-activated protein kinase 14 / 0.658
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.658
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.655
3uvq FS8Mitogen-activated protein kinase 14 / 0.654
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.650