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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nlb 5BE Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.873
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.738
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.715
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.708
3vid 4TTVascular endothelial growth factor receptor 2 2.7.10.1 0.700
3w16 P9JAurora kinase A 2.7.11.1 0.689
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.688
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.681
4f64 0S8Fibroblast growth factor receptor 1 / 0.681
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.675
2w1g L0GAurora kinase A 2.7.11.1 0.671
4b8m VX6Aurora kinase B-A 2.7.11.1 0.671
4nks 2M2Fibroblast growth factor receptor 1 / 0.670
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.665
2w1f L0FAurora kinase A 2.7.11.1 0.662
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2xne ASHAurora kinase A 2.7.11.1 0.659
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.656
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.655
4bkz 1WSMaternal embryonic leucine zipper kinase 2.7.11.1 0.655
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.654
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4jbq VX6Aurora kinase A 2.7.11.1 0.652
4f63 0S7Fibroblast growth factor receptor 1 / 0.650