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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nie ANP Mitogen-activated protein kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nie ANPMitogen-activated protein kinase / 1.100
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.829
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.826
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.824
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.816
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.796
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.785
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.776
3ori AGSSerine/threonine protein kinase / 0.768
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.767
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.766
3orm AGSSerine/threonine protein kinase / 0.763
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.758
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.756
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.756
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.749
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.748
2pui ADPMethylthioribose kinase 2.7.1.100 0.744
3c4w ATPRhodopsin kinase / 0.741
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.740
2dwb ANPAurora kinase A 2.7.11.1 0.737
3cly ACPFibroblast growth factor receptor 2 / 0.735
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.735
4ceg ADPAurora kinase A 2.7.11.1 0.735
1mq4 ADPAurora kinase A 2.7.11.1 0.733
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.730
2pul ACPMethylthioribose kinase 2.7.1.100 0.729
4bn1 ADPAurora kinase A 2.7.11.1 0.728
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.726
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.724
2py3 ACPFibroblast growth factor receptor 2 / 0.722
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.719
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.717
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.716
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.716
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.715
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.711
3c4z ADPRhodopsin kinase / 0.711
4o4e ATPKinase / 0.711
4o1p ANPRibonuclease L / 0.710
4o4f ATPKinase / 0.710
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.707
4ysj ADPCalmodulin-like domain protein kinase / 0.707
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.706
4dee ADPAurora kinase A 2.7.11.1 0.704
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.704
2olc ADPMethylthioribose kinase 2.7.1.100 0.702
2pz5 ACPFibroblast growth factor receptor 2 / 0.702
2pzp ACPFibroblast growth factor receptor 2 / 0.702
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.701
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.700
3t8o ATPRhodopsin kinase / 0.700
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.700
4utd ACPAurora kinase A 2.7.11.1 0.700
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
5eg3 ACPFibroblast growth factor receptor 2 / 0.699
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.698
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.697
3oro AGSSerine/threonine protein kinase / 0.697
3ort AGSSerine/threonine protein kinase / 0.697
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.697
3orp AGSSerine/threonine protein kinase / 0.696
5dr2 ATPAurora kinase A 2.7.11.1 0.695
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.693
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.692
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4qny ANPMitogen activated protein kinase, putative / 0.691
5dt4 ATPAurora kinase A 2.7.11.1 0.691
3c50 ADPRhodopsin kinase / 0.690
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.690
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.690
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.688
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.688
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.688
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.687
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.687
3qc9 ADPRhodopsin kinase / 0.686
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.684
4o4d ATPKinase / 0.684
3llt ANPProtein serine/threonine kinase-1 / 0.683
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.683
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.682
2pyw ADPMethylthioribose kinase 2.7.1.100 0.682
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.681
4ffr ATPUncharacterized protein / 0.681
5dt3 ATPAurora kinase A 2.7.11.1 0.681
4xlv ACPInsulin receptor 2.7.10.1 0.680
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4zgn ATPCell division cycle protein 123 / 0.677
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.676
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.673
5l8j ADPAurora kinase A 2.7.11.1 0.673
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.672
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.672
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.671
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.670
4o0u ADNAurora kinase A 2.7.11.1 0.670
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.668
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.667
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.667
5dnr ATPAurora kinase A 2.7.11.1 0.667
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.666
2pup ADPMethylthioribose kinase 2.7.1.100 0.665
3bu5 ATPInsulin receptor 2.7.10.1 0.665
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.664
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.664
1ol5 ADPAurora kinase A 2.7.11.1 0.663
2z08 ATPUniversal stress protein family / 0.663
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.663
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.662
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.660
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.659
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.659
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.659
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.658
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.657
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.655
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.655
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.655
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.654
5dn3 ATPAurora kinase A 2.7.11.1 0.654
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.653
2hux SAHDiphthine synthase / 0.653
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.653
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.653
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.653
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.652
4c3r ACPAurora kinase A 2.7.11.1 0.652
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.651
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.650
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.650
4pzk SAHPutative tRNA (cytidine(34)-2'-O)-methyltransferase / 0.650