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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3n82 NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.140
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.076
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.040
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 1.015
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.986
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.949
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.930
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.906
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.892
4pxl NADAldehyde dehydrogenase3 / 0.892
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.873
4pt0 NADAldehyde dehydrogenase / 0.859
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.853
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.853
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.791
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.790
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.788
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.782
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.775
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.771
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.770
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.763
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.759
4i8p NADAminoaldehyde dehydrogenase 1 / 0.759
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.749
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.742
4i9b NADPutative betaine aldehyde dehyrogenase / 0.742
3b4w NADAldehyde dehydrogenase family protein / 0.740
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.740
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.736
4f3x NADPutative aldehyde dehydrogenase / 0.730
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.729
4pt3 NDPAldehyde dehydrogenase / 0.728
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.727
3iwj NADAminoaldehyde dehydrogenase / 0.723
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.722
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.721
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.720
4i3w NADAldehyde dehydrogenase (NAD+) / 0.720
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.713
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.712
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.710
4i8q NADPutative betaine aldehyde dehyrogenase / 0.704
4pz2 NADAldehyde dehydrogenase 2-6 / 0.703
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.702
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.702
1bi9 NADRetinal dehydrogenase 2 / 0.700
5dib NADBetaine-aldehyde dehydrogenase / 0.700
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.695
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.695
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.692
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.692
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.691
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.690
4i3v NADAldehyde dehydrogenase (NAD+) / 0.690
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.688
5eyu NADBetaine-aldehyde dehydrogenase / 0.683
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.681
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.679
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.676
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.673
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.670
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.669
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.664
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.663
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.661
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.659
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.655
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.654
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.653
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.650