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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mvm 39P Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3mvm 39PMitogen-activated protein kinase 14 / 0.986
2rg6 287Mitogen-activated protein kinase 14 / 0.932
4kin 1M8Mitogen-activated protein kinase 14 / 0.826
4kiq 1RAMitogen-activated protein kinase 14 / 0.826
3s4q NK0Mitogen-activated protein kinase 14 / 0.816
3ocg OCGMitogen-activated protein kinase 14 / 0.801
4kip 1R9Mitogen-activated protein kinase 14 / 0.789
3bx5 304Mitogen-activated protein kinase 14 / 0.783
2rg5 279Mitogen-activated protein kinase 14 / 0.763
3l8x N4DMitogen-activated protein kinase 14 / 0.754
3gfe P37Mitogen-activated protein kinase 14 / 0.753
4aa5 NQBMitogen-activated protein kinase 14 / 0.753
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.746
3bv3 P39Mitogen-activated protein kinase 14 / 0.745
3itz P66Mitogen-activated protein kinase 14 / 0.734
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.724
3fkl FKLMitogen-activated protein kinase 14 / 0.719
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.719
4aac AAVMitogen-activated protein kinase 14 / 0.705
3fsk RO6Mitogen-activated protein kinase 14 / 0.700
4aa4 QC0Mitogen-activated protein kinase 14 / 0.699
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.697
3lfa 1N1Mitogen-activated protein kinase 14 / 0.696
3fsf FSSMitogen-activated protein kinase 14 / 0.679
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.679
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.667
3iph G11Mitogen-activated protein kinase 14 / 0.666
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.666
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.664
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.664
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.663
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.662
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.660
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.650
3e92 G6AMitogen-activated protein kinase 14 / 0.650
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.650