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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mvl 38P Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3mvl 38PMitogen-activated protein kinase 14 / 1.062
3s4q NK0Mitogen-activated protein kinase 14 / 0.760
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.719
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.702
4aa5 NQBMitogen-activated protein kinase 14 / 0.696
3dt1 P40Mitogen-activated protein kinase 14 / 0.693
3fkl FKLMitogen-activated protein kinase 14 / 0.691
4kiq 1RAMitogen-activated protein kinase 14 / 0.687
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.680
3e92 G6AMitogen-activated protein kinase 14 / 0.675
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.674
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.673
3u8w 09JMitogen-activated protein kinase 14 / 0.672
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.667
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.667
3rin I2OMitogen-activated protein kinase 14 / 0.663
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.657
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.655
2rg6 287Mitogen-activated protein kinase 14 / 0.654
2zb1 GK4Mitogen-activated protein kinase 14 / 0.654
3e93 19BMitogen-activated protein kinase 14 / 0.653