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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m4h 388 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3m4h 388Aldose reductase 1.1.1.21 1.102
3ld5 LDTAldose reductase 1.1.1.21 1.024
3ghu LDTAldose reductase 1.1.1.21 1.015
3lbo LDTAldose reductase 1.1.1.21 1.015
3lql LDTAldose reductase 1.1.1.21 0.995
3ght LDTAldose reductase 1.1.1.21 0.992
2qxw LDTAldose reductase 1.1.1.21 0.978
2iki 388Aldose reductase 1.1.1.21 0.975
3ghr LDTAldose reductase 1.1.1.21 0.975
3ghs LDTAldose reductase 1.1.1.21 0.975
3lz5 LDTAldose reductase 1.1.1.21 0.962
2i17 LDTAldose reductase 1.1.1.21 0.960
1us0 LDTAldose reductase 1.1.1.21 0.959
2i16 LDTAldose reductase 1.1.1.21 0.959
2pdj 393Aldose reductase 1.1.1.21 0.857
2ikj 393Aldose reductase 1.1.1.21 0.855
3m64 393Aldose reductase 1.1.1.21 0.849
2pdc 393Aldose reductase 1.1.1.21 0.826
2pdu 393Aldose reductase 1.1.1.21 0.812
2pdp 393Aldose reductase 1.1.1.21 0.796
1iei ZESAldose reductase 1.1.1.21 0.795
2pzn 393Aldose reductase 1.1.1.21 0.793
3mc5 393Aldose reductase 1.1.1.21 0.791
1t41 ID5Aldose reductase 1.1.1.21 0.788
1pwl BFIAldose reductase 1.1.1.21 0.779
2fz8 ZSTAldose reductase 1.1.1.21 0.777
3t42 3T4Aldose reductase 1.1.1.21 0.763
2duz ZSTAldose reductase 1.1.1.21 0.761
2pdi ZSTAldose reductase 1.1.1.21 0.747
1t40 ID5Aldose reductase 1.1.1.21 0.744
3g5e Q74Aldose reductase 1.1.1.21 0.744
2dux ZSTAldose reductase 1.1.1.21 0.741
2pd5 ZSTAldose reductase 1.1.1.21 0.738
1z3n 3NAAldose reductase 1.1.1.21 0.729
2fz9 ZSTAldose reductase 1.1.1.21 0.717
2pdh 47DAldose reductase 1.1.1.21 0.717
3s3g TLTAldose reductase 1.1.1.21 0.717
2pdx ZSTAldose reductase 1.1.1.21 0.714
2inz OHPAldose reductase 1.1.1.21 0.709
2ikh LITAldose reductase 1.1.1.21 0.707
4gca 2X9Aldose reductase 1.1.1.21 0.706
2pdl TOLAldose reductase 1.1.1.21 0.705
2pdf ZSTAldose reductase 1.1.1.21 0.702
2nvc ITAAldose reductase 1.1.1.21 0.690
4yu1 53NAldose reductase 1.1.1.21 0.690
1z89 62PAldose reductase 1.1.1.21 0.689
2fzd TOLAldose reductase 1.1.1.21 0.678
2pdq 47DAldose reductase 1.1.1.21 0.666
3mb9 ZSTAldose reductase 1.1.1.21 0.652