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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lxp IZA Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lxp IZANon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.944
3eyh IZATyrosine-protein kinase JAK1 / 0.766
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.689
2b7a IZATyrosine-protein kinase JAK2 / 0.683
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.680
4ft3 H1KSerine/threonine-protein kinase Chk1 2.7.11.1 0.671
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.650