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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lpk Z76 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lpk Z76Beta-secretase 1 3.4.23.46 1.605
3lpi Z74Beta-secretase 1 3.4.23.46 1.306
3cib 314Beta-secretase 1 3.4.23.46 1.214
2iqg F2IBeta-secretase 1 3.4.23.46 1.130
3cic 316Beta-secretase 1 3.4.23.46 1.095
3cid 318Beta-secretase 1 3.4.23.46 1.067
3lpj Z75Beta-secretase 1 3.4.23.46 1.020
2p83 MR0Beta-secretase 1 3.4.23.46 0.965
4lxa 1YSBeta-secretase 1 3.4.23.46 0.911
2vie VG0Beta-secretase 1 3.4.23.46 0.880
2viz VG4Beta-secretase 1 3.4.23.46 0.878
2hm1 LIQBeta-secretase 1 3.4.23.46 0.876
3r2f PB0Beta-secretase 1 3.4.23.46 0.876
3qi1 C6ABeta-secretase 1 3.4.23.46 0.870
3ohh 3HHBeta-secretase 1 3.4.23.46 0.868
2vj7 VG6Beta-secretase 1 3.4.23.46 0.862
4lxk 1YTBeta-secretase 1 3.4.23.46 0.855
3qbh QBHBeta-secretase 1 3.4.23.46 0.849
3dv5 BAVBeta-secretase 1 3.4.23.46 0.844
2vnm CM8Beta-secretase 1 3.4.23.46 0.838
4d89 BXDBeta-secretase 1 3.4.23.46 0.838
2vnn CM7Beta-secretase 1 3.4.23.46 0.829
4dpf 0LGBeta-secretase 1 3.4.23.46 0.822
2xfi XFIBeta-secretase 1 3.4.23.46 0.819
3k5g BJCBeta-secretase 1 3.4.23.46 0.819
4fco 0U4Beta-secretase 1 3.4.23.46 0.818
2vij C44Beta-secretase 1 3.4.23.46 0.799
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.792
1w51 L01Beta-secretase 1 3.4.23.46 0.788
2fdp FRPBeta-secretase 1 3.4.23.46 0.782
2hiz LIJBeta-secretase 1 3.4.23.46 0.781
2xfj VG5Beta-secretase 1 3.4.23.46 0.776
3dm6 757Beta-secretase 1 3.4.23.46 0.776
2viy VG3Beta-secretase 1 3.4.23.46 0.774
2xfk AA9Beta-secretase 1 3.4.23.46 0.771
4exg 916Beta-secretase 1 3.4.23.46 0.768
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.766
3ohf 3HFBeta-secretase 1 3.4.23.46 0.765
4ewo 996Beta-secretase 1 3.4.23.46 0.764
3vg1 0GTBeta-secretase 1 3.4.23.46 0.763
4k9h 1QUBeta-secretase 1 3.4.23.46 0.763
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.760
3pi5 3P5Beta-secretase 1 3.4.23.46 0.759
3vf3 0GSBeta-secretase 1 3.4.23.46 0.759
2p8h MY9Beta-secretase 1 3.4.23.46 0.757
4ke0 1R8Beta-secretase 1 3.4.23.46 0.752
2vkm BSDBeta-secretase 1 3.4.23.46 0.750
4ke1 1R6Beta-secretase 1 3.4.23.46 0.744
3tpr 5HABeta-secretase 1 3.4.23.46 0.743
3skg PB8Beta-secretase 1 3.4.23.46 0.742
3n4l 842Beta-secretase 1 3.4.23.46 0.736
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.735
3i25 MV7Beta-secretase 1 3.4.23.46 0.735
2qzl IXSBeta-secretase 1 3.4.23.46 0.734
3pww ROCEndothiapepsin 3.4.23.22 0.732
2b8v 3BNBeta-secretase 1 3.4.23.46 0.730
3k5f AYHBeta-secretase 1 3.4.23.46 0.729
4k8s 1QTBeta-secretase 1 3.4.23.46 0.722
2b8l 5HABeta-secretase 1 3.4.23.46 0.713
3ixj 586Beta-secretase 1 3.4.23.46 0.709
3k5c 0BIBeta-secretase 1 3.4.23.46 0.709
2f3e AXQBeta-secretase 1 3.4.23.46 0.703
2f3f AXFBeta-secretase 1 3.4.23.46 0.698
1gvv 0GMEndothiapepsin 3.4.23.22 0.696
3veu 0GOBeta-secretase 1 3.4.23.46 0.696
2wez ZYEBeta-secretase 1 3.4.23.46 0.695
3duy AFJBeta-secretase 1 3.4.23.46 0.695
2p4j 23IBeta-secretase 1 3.4.23.46 0.689
1psa 0ZLPepsin A 3.4.23.1 0.684
2vj9 VG7Beta-secretase 1 3.4.23.46 0.682
3nsh 957Beta-secretase 1 3.4.23.46 0.678
4i0i 957Beta-secretase 1 3.4.23.46 0.678
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.675
3ixk 929Beta-secretase 1 3.4.23.46 0.671
4gid 0GHBeta-secretase 1 3.4.23.46 0.671
3own 3OXRenin 3.4.23.15 0.667
2vj6 VG5Beta-secretase 1 3.4.23.46 0.666
3slz 3TLPutative gag-pro-pol polyprotein / 0.662
2g94 ZPQBeta-secretase 1 3.4.23.46 0.656