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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lmg ANP Receptor tyrosine-protein kinase erbB-3 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 1.051
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.861
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.843
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.806
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.787
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.768
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.752
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.717
1zyd ATPeIF-2-alpha kinase GCN2 / 0.693
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.690
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.688
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.687
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.686
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.682
4col DTPUncharacterized protein / 0.676
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.668
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.667
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.665
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.662
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.662
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.661
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.658
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.657
4coj DTPUncharacterized protein / 0.656
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.653
3t0z ATPHeat shock protein HSP 90-alpha / 0.651
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.650
4wud ANPDNA gyrase subunit B / 0.650