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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lfs A07 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.988
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.923
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.742
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.728
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.724
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.719
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.703
3sqq 99ZCyclin-dependent kinase 2 2.7.11.22 0.702
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.699
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.696
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.695
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.695
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.693
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.692
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.691
3r8l Z30Cyclin-dependent kinase 2 2.7.11.22 0.691
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.690
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.688
3ig7 EFPCyclin-dependent kinase 2 2.7.11.22 0.682
2r3g SC9Cyclin-dependent kinase 2 2.7.11.22 0.680
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.677
2b54 D05Cyclin-dependent kinase 2 2.7.11.22 0.677
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.677
2vto LZ8Cyclin-dependent kinase 2 2.7.11.22 0.676
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
2vtq LZACyclin-dependent kinase 2 2.7.11.22 0.674
4twp AXITyrosine-protein kinase ABL1 2.7.10.2 0.673
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.672
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.664
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
2vu3 LZECyclin-dependent kinase 2 2.7.11.22 0.662
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.662
4fv8 E63Mitogen-activated protein kinase 1 2.7.11.24 0.660
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.659
3w16 P9JAurora kinase A 2.7.11.1 0.659
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.659
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.655
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.655
2j50 627Aurora kinase A 2.7.11.1 0.653
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.653
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.653
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.652
2fvd LIACyclin-dependent kinase 2 2.7.11.22 0.652
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.652
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.651
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.650