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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lff Z83 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lff Z83Mitogen-activated protein kinase 14 / 1.034
3lfb Z87Mitogen-activated protein kinase 14 / 0.856
3hv3 R49Mitogen-activated protein kinase 14 / 0.843
3hv6 R39Mitogen-activated protein kinase 14 / 0.840
3pg3 DG7Mitogen-activated protein kinase 14 / 0.831
3lfe Z84Mitogen-activated protein kinase 14 / 0.819
3gcq 1BUMitogen-activated protein kinase 14 / 0.813
3uvr 06FMitogen-activated protein kinase 14 / 0.811
2puu G2GMitogen-activated protein kinase 14 / 0.791
3hv5 R24Mitogen-activated protein kinase 14 / 0.780
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.774
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.772
3hv7 1AUMitogen-activated protein kinase 14 / 0.761
1w82 L10Mitogen-activated protein kinase 14 / 0.754
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.748
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.748
3hv4 L51Mitogen-activated protein kinase 14 / 0.746
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.745
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.745
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.737
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.734
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.732
3lfc Z86Mitogen-activated protein kinase 14 / 0.729
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.724
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.720
1kv2 B96Mitogen-activated protein kinase 14 / 0.710
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.710
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.709
3p5k P5KMitogen-activated protein kinase 14 / 0.704
3gcu R48Mitogen-activated protein kinase 14 / 0.700
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.697
3gi3 B10Mitogen-activated protein kinase 14 / 0.691
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.682
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.680
2yis YISMitogen-activated protein kinase 14 / 0.675
2yiw YIWMitogen-activated protein kinase 14 / 0.675
3nnw EDDMitogen-activated protein kinase 14 / 0.673
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.666
3nnx EDDMitogen-activated protein kinase 14 / 0.663
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.658
3p7c P7CMitogen-activated protein kinase 14 / 0.650