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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3le6 2BZ Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.923
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.770
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.741
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.740
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.728
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.724
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.717
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.711
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.695
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.695
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.691
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.687
2r3q 5SCCyclin-dependent kinase 2 2.7.11.22 0.683
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.682
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.681
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.681
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.681
2b54 D05Cyclin-dependent kinase 2 2.7.11.22 0.680
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.679
3zmm F9JTyrosine-protein kinase JAK2 / 0.679
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.678
2r3o 2SCCyclin-dependent kinase 2 2.7.11.22 0.677
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.672
2vtq LZACyclin-dependent kinase 2 2.7.11.22 0.669
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.668
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.666
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.665
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.664
4kd1 1QKCyclin-dependent kinase 2 2.7.11.22 0.663
2r3i SCFCyclin-dependent kinase 2 2.7.11.22 0.661
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.660
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.659
4f63 0S7Fibroblast growth factor receptor 1 / 0.657
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.656
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.656
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.656
2ds1 1CDCyclin-dependent kinase 2 2.7.11.22 0.654
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.654
3gb2 G3BGlycogen synthase kinase-3 beta 2.7.11.26 0.652
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.652
4nks 2M2Fibroblast growth factor receptor 1 / 0.652
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.651