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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lct ADP ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.795
4e5i 0N9Polymerase acidic protein / 0.744
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.737
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.718
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.718
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.717
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.714
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.705
1zyd ATPeIF-2-alpha kinase GCN2 / 0.701
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.701
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.697
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.697
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.696
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.691
3b2t M33Fibroblast growth factor receptor 2 / 0.687
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.685
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.682
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.682
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.679
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.678
5ckw ANPUncharacterized protein / 0.677
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.676
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.676
4xhg ADPUncharacterized protein / 0.675
3c4w ATPRhodopsin kinase / 0.674
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.673
3t8o ATPRhodopsin kinase / 0.672
3tei ANPMitogen-activated protein kinase 1 2.7.11.24 0.672
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4lv8 ADPRhoptry protein 5 C / 0.672
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.671
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.670
3a8w ATPProtein kinase C iota type 2.7.11.13 0.669
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.668
1ad5 ANPTyrosine-protein kinase HCK 2.7.10.2 0.667
1n2v BDIQueuine tRNA-ribosyltransferase 2.4.2.29 0.667
3q60 ATPRhoptry protein 5B / 0.667
2wgh DTPRibonucleoside-diphosphate reductase large subunit 1.17.4.1 0.666
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.665
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.665
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.665
4j95 ACPFibroblast growth factor receptor 2 / 0.664
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.663
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.663
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.663
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.662
4mv4 ACPBiotin carboxylase 6.3.4.14 0.662
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.661
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
3c4x ATPRhodopsin kinase / 0.661
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.661
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.660
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.660
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.659
3q5i ANPProtein kinase, putative / 0.659
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
3c4z ADPRhodopsin kinase / 0.657
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.657
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.657
4ix5 ANPUncharacterized protein / 0.656
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.656
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.655
4fvr ATPTyrosine-protein kinase JAK2 / 0.655
3w0q ANPHygromycin-B 4-O-kinase 2.7.1.163 0.654
3d5w ADPSerine/threonine-protein kinase PLK / 0.653
3tlj SAHUncharacterized protein / 0.653
4mv1 ADPBiotin carboxylase 6.3.4.14 0.653
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.653
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.652
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.652
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.652
2dwb ANPAurora kinase A 2.7.11.1 0.651
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4ix4 ADPUncharacterized protein / 0.651
5dos ATPAurora kinase A 2.7.11.1 0.651
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.651
3hx4 ANPCalmodulin-domain protein kinase 1 / 0.650