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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l8p 0CE Angiopoietin-1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 1.187
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.728
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.716
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.698
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.694
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.690
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.688
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.685
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.682
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.671
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.671
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.670
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.666
3vs2 VSBTyrosine-protein kinase HCK 2.7.10.2 0.664
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.663
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.660
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.650