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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l5l FMN Xenobiotic reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3l5l FMNXenobiotic reductase / 1.256
4utm FNRXenobiotic reductase / 1.234
3l67 FMNXenobiotic reductase / 1.225
4uth FMNXenobiotic reductase / 1.225
5cpm FNRNADH:flavin oxidoreductase / 1.212
2h8x FMNXenA / 1.202
4utk FNRXenobiotic reductase / 1.190
3n14 FMNXenobiotic reductase / 1.185
3n19 FNRXenobiotic reductase / 1.138
4utl FNRXenobiotic reductase / 1.121
2gou FMNNADH:flavin oxidoreductase Sye1 / 1.089
1z44 FMNNADPH dehydrogenase / 1.073
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.067
3hf3 FMNChromate reductase / 1.007
1z41 FMNNADPH dehydrogenase / 0.995
3tjl FMNNADPH dehydrogenase / 0.988
1z48 FMNNADPH dehydrogenase / 0.987
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.986
4df2 FMNNADPH dehydrogenase / 0.972
4m5p FMNNADPH dehydrogenase / 0.967
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.963
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.962
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.945
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.941
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.938
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.933
4tmc FMNOld yellow enzyme / 0.929
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.920
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.920
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.904
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.902
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.901
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.897
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.893
3gr8 FMNNADPH dehydrogenase / 0.892
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.891
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.886
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.885
1vhn FMNtRNA-dihydrouridine synthase / 0.882
1h51 FMNPentaerythritol tetranitrate reductase / 0.880
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.879
1gwj FMNMorphinone reductase / 0.869
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.863
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.861
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.860
4yco FMNtRNA-dihydrouridine(16) synthase / 0.859
3p84 FMNPentaerythritol tetranitrate reductase / 0.858
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.855
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.852
2abb FMNPentaerythritol tetranitrate reductase / 0.851
1vyr FMNPentaerythritol tetranitrate reductase / 0.850
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.849
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.848
3p74 FMNPentaerythritol tetranitrate reductase / 0.845
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.843
3f03 FMNPentaerythritol tetranitrate reductase / 0.842
3p8j FMNPentaerythritol tetranitrate reductase / 0.842
4tmb FMNOld yellow enzyme / 0.842
1h50 FMNPentaerythritol tetranitrate reductase / 0.841
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.841
3p82 FMNPentaerythritol tetranitrate reductase / 0.838
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.838
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.838
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.837
4e2d FMNDehydrogenase / 0.837
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.836
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.836
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.834
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.830
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.830
2nli FMNLactate oxidase / 0.825
3p67 FMNPentaerythritol tetranitrate reductase / 0.819
3p62 FMNPentaerythritol tetranitrate reductase / 0.818
2j6x FMNLactate oxidase / 0.817
2zfa FMNLactate oxidase / 0.817
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.815
4qai FMNNADPH dehydrogenase / 0.815
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.810
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.810
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.806
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.805
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.789
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.787
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.785
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.785
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.781
1h63 FMNPentaerythritol tetranitrate reductase / 0.777
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.774
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.770
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.770
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.767
3gka FMNN-ethylmaleimide reductase / 0.765
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.764
2du2 FMNLactate oxidase / 0.764
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.763
4e2b FMNDehydrogenase / 0.762
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.758
2z6i FMN2-nitropropane dioxygenase / 0.758
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.757
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.757
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.756
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.749
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.748
4cw5 FMNDfnA / 0.747
2e77 FMNLactate oxidase / 0.739
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.738
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.733
4rje FNRLactate oxidase / 0.733
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.731
3oix FMNDihydroorotate dehydrogenase / 0.729
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.726
3aty FMNProstaglandin F2a synthase / 0.723
2b3d FADModulator of drug activity B / 0.722
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.720
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.716
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.715
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.704
5ebu FMNLactate oxidase / 0.700
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.699
4jic FMNGTN Reductase / 0.697
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.686
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.682
4q4k FMNUncharacterized protein / 0.682
2oz0 FMNCytochrome b2, mitochondrial 1.1.2.3 0.681
2z9d FMNFMN-dependent NADH-azoreductase / 0.681
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.680
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.676
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.676
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.676
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.675
3w77 FMNFMN-dependent NADH-azoreductase / 0.675
2g86 UMPThymidylate synthase / 0.673
2gjn FMNNitronate monooxygenase 1.13.12.16 0.673
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.672
2vxa RBFDodecin / 0.669
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.668
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.666
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.662
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.660
1r2j FADFkbI / 0.660
4j8p FMNFlavodoxin / 0.659
3n3a FMNProtein NrdI / 0.656
2reh FADNitroalkane oxidase 1.7.3.1 0.655
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.654
4yl2 FMNLactate oxidase / 0.652
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.651
4z38 FMNMlnA / 0.650