sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 1.321 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 1.296 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 1.131 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 1.044 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 1.024 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.990 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.985 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.973 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.971 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.970 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.965 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.958 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.957 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.945 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.944 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.938 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.929 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.916 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.911 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.907 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.906 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.899 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.892 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.883 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.874 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.874 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.870 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.860 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.858 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.857 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.851 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.843 | |
| 4hxy | NDP | Plm1 | / | 0.838 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.835 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.820 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.818 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.813 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.812 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.811 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.810 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.808 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.805 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.803 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.801 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.800 | |
| 4u7w | NDP | MxaA | / | 0.799 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.797 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.795 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.792 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.791 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.789 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.786 | |
| 3mje | NDP | AmphB | / | 0.782 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.782 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.779 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.778 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.777 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.777 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.773 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.771 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.766 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.764 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.762 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.760 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.759 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.758 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.756 | |
| 3bmo | NAP | Pteridine reductase | / | 0.755 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.754 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.753 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.753 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.753 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.753 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.753 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.751 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.749 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.748 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.748 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.745 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.744 | |
| 4qec | NAP | ElxO | / | 0.744 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.743 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.743 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.742 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.742 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.742 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.741 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.740 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.740 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.739 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.739 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.739 | |
| 4qed | NAP | ElxO | / | 0.737 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.736 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.736 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.735 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.735 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.735 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.735 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.735 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.734 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.734 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.733 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.732 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.732 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.732 | |
| 1iy8 | NAD | Levodione reductase | / | 0.730 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.730 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.729 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.728 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.728 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.726 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.726 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.726 | |
| 3qvs | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.725 | |
| 3qvx | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.725 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.725 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.724 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.723 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.723 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.722 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.721 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.719 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.719 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.719 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.717 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.716 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.716 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.714 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.713 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.712 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.712 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.711 | |
| 3uce | NDP | Dehydrogenase | / | 0.710 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.710 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.709 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.709 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.709 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.708 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.708 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.706 | |
| 4clo | NAP | Pteridine reductase | / | 0.704 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.703 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.703 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.703 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.702 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.702 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.702 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.701 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.701 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.700 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.700 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.700 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.699 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.698 | |
| 2o07 | MTA | Spermidine synthase | 2.5.1.16 | 0.698 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.698 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.698 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.698 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.698 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.698 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.697 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.697 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.694 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.694 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.694 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.693 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.693 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.692 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.692 | |
| 1sny | NAP | LD36273p | / | 0.690 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.690 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.690 | |
| 2ixb | NAD | Alpha-N-acetylgalactosaminidase | 3.2.1.49 | 0.689 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.688 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.688 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.687 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.687 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.687 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.687 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.686 | |
| 2z6u | SAH | Modification methylase HhaI | 2.1.1.37 | 0.686 | |
| 4y9d | NAI | C alpha-dehydrogenase | / | 0.686 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.685 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.684 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.683 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.683 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.683 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.682 | |
| 4mb2 | ATP | Uncharacterized protein | / | 0.681 | |
| 4yuv | S4M | Spermidine synthase, putative | / | 0.681 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.680 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.680 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.680 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.680 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.679 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.679 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.678 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.677 | |
| 1p1i | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.676 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.676 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.676 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.675 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.675 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.674 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.674 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.673 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.673 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.672 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.670 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.669 | |
| 4yv1 | S4M | Spermidine synthase, putative | / | 0.669 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.668 | |
| 3nt2 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.668 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.667 | |
| 1eg2 | MTA | Modification methylase RsrI | 2.1.1.72 | 0.667 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.667 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.667 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.667 | |
| 3sju | NDP | Keto reductase | / | 0.667 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.667 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.666 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.666 | |
| 4kwh | NAP | Reductase homolog | / | 0.666 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.665 | |
| 3qow | SAM | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.665 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.665 | |
| 4l4x | NDP | AmphI | / | 0.664 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.664 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.663 | |
| 3rw9 | DSH | Spermidine synthase | 2.5.1.16 | 0.663 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.662 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.661 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.661 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.661 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.660 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.660 | |
| 1x7d | NAD | Putative ornithine cyclodeaminase | / | 0.659 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.659 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.658 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.658 | |
| 3bgv | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.658 | |
| 2np6 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.657 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.657 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.656 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.655 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.655 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.654 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.654 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.654 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.654 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.653 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.653 | |
| 3nlc | FAD | Uncharacterized protein | / | 0.653 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.653 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.653 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.651 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.651 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.651 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.650 | |
| 3lfz | ADP | Uncharacterized protein MJ1225 | / | 0.650 | |
| 5je2 | SAH | Methyl transferase | / | 0.650 |