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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3klm DHT Estradiol 17-beta-dehydrogenase 1 1.1.1.62

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.982
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.982
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.820
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.770
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.762
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
1kdm DHTSex hormone-binding globulin / 0.721
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.696
3uzz TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.679
3w5p 4OAVitamin D3 receptor / 0.679
4k7a DHTAndrogen receptor / 0.662
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4c49 HCYCorticosteroid-binding globulin / 0.659
3ov4 EQUSteroid Delta-isomerase 5.3.3.1 0.653
4at2 ASDPossible succinate dehydrogenase / 0.652
2jn3 JN3Fatty acid-binding protein, liver / 0.650