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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kkv B99 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.163
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.898
5dgz L20Serine/threonine-protein kinase pim-1 2.7.11.1 0.835
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.831
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.814
2uzv SS5cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.798
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.797
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.793
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
2ojf 4PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
2jdt I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.687
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.672
4bkz 1WSMaternal embryonic leucine zipper kinase 2.7.11.1 0.672
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.670
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.664
2yi6 6QMHeat shock protein HSP 90-alpha / 0.656
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.650
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.650