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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kjs DQ1 Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 1.044
3r33 6MEDihydrofolate reductase 1.5.1.3 0.722
1s3y TQTDihydrofolate reductase 1.5.1.3 0.686
1dra MTXDihydrofolate reductase 1.5.1.3 0.664
1df7 MTXDihydrofolate reductase 1.5.1.3 0.660
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.656
4ixf IXFDihydrofolate reductase 1.5.1.3 0.656
1u72 MTXDihydrofolate reductase 1.5.1.3 0.653
4ixg IXGDihydrofolate reductase 1.5.1.3 0.653
1dds MTXDihydrofolate reductase 1.5.1.3 0.650