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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ix9 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ix9 MTXDihydrofolate reductase 1.5.1.3 1.158
3dau MTXDihydrofolate reductase 1.5.1.3 0.918
2zza FOLDihydrofolate reductase / 0.874
3ia4 MTXDihydrofolate reductase / 0.867
2qk8 MTXDihydrofolate reductase / 0.857
5hi6 MTXDihydrofolate reductase / 0.847
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.841
3och 2MXDihydrofolate reductase 1.5.1.3 0.836
1df7 MTXDihydrofolate reductase 1.5.1.3 0.822
4dfr MTXDihydrofolate reductase 1.5.1.3 0.816
1dra MTXDihydrofolate reductase 1.5.1.3 0.814
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.814
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.809
2drc MTXDihydrofolate reductase 1.5.1.3 0.808
3dfr MTXDihydrofolate reductase 1.5.1.3 0.808
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.807
3eig MTXDihydrofolate reductase 1.5.1.3 0.807
4p66 MTXDihydrofolate reductase / 0.804
3frd DHFDihydrofolate reductase 1.5.1.3 0.800
4m6k FOLDihydrofolate reductase 1.5.1.3 0.800
3drc MTXDihydrofolate reductase 1.5.1.3 0.799
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.799
1dre MTXDihydrofolate reductase 1.5.1.3 0.797
1hfp MOTDihydrofolate reductase 1.5.1.3 0.792
1jol FFODihydrofolate reductase 1.5.1.3 0.792
1tdr MTXDihydrofolate reductase 1.5.1.3 0.785
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.783
4i1n FOLDihydrofolate reductase 1.5.1.3 0.782
1hfr MOTDihydrofolate reductase 1.5.1.3 0.779
4kjj FOLDihydrofolate reductase 1.5.1.3 0.778
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.772
4qi9 MTXDihydrofolate reductase / 0.769
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.767
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.766
1u70 MTXDihydrofolate reductase 1.5.1.3 0.763
1dls MTXDihydrofolate reductase 1.5.1.3 0.762
1drf FOLDihydrofolate reductase 1.5.1.3 0.761
1hfq MOTDihydrofolate reductase 1.5.1.3 0.758
3tq9 MTXDihydrofolate reductase / 0.758
1e26 GPBDihydrofolate reductase 1.5.1.3 0.755
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.753
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.751
4x5f FOLDihydrofolate reductase 1.5.1.3 0.751
1jom FFODihydrofolate reductase 1.5.1.3 0.742
4i13 FOLDihydrofolate reductase 1.5.1.3 0.742
4x5g FOLDihydrofolate reductase 1.5.1.3 0.742
1u72 MTXDihydrofolate reductase 1.5.1.3 0.738
2d0k FOLDihydrofolate reductase 1.5.1.3 0.736
4x5i FOLDihydrofolate reductase 1.5.1.3 0.736
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.734
4p68 MTXDihydrofolate reductase / 0.734
7dfr FOLDihydrofolate reductase 1.5.1.3 0.733
1ohj COPDihydrofolate reductase 1.5.1.3 0.732
4fhb FOLDihydrofolate reductase 1.5.1.3 0.732
1dyj DDFDihydrofolate reductase 1.5.1.3 0.731
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.731
3dat MTXDihydrofolate reductase / 0.729
1drb MTXDihydrofolate reductase 1.5.1.3 0.726
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.726
1dhf FOLDihydrofolate reductase 1.5.1.3 0.725
1dhi MTXDihydrofolate reductase 1.5.1.3 0.725
1dyi FOLDihydrofolate reductase 1.5.1.3 0.723
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.723
1dhj MTXDihydrofolate reductase 1.5.1.3 0.720
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.718
2w3m FOLDihydrofolate reductase 1.5.1.3 0.718
4x5h FOLDihydrofolate reductase 1.5.1.3 0.716
2dhf DZFDihydrofolate reductase 1.5.1.3 0.713
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.712
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.712
1dyh DZFDihydrofolate reductase 1.5.1.3 0.710
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.708
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.705
4kfj FOLDihydrofolate reductase 1.5.1.3 0.702
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.693
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.686
4m6l 21VDihydrofolate reductase 1.5.1.3 0.685
4keb FOLDihydrofolate reductase 1.5.1.3 0.684
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.680
1re7 FOLDihydrofolate reductase 1.5.1.3 0.675
4m7v RARDihydrofolate reductase / 0.675
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.674
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.671
3ghv GHCDihydrofolate reductase 1.5.1.3 0.670
4ixg IXGDihydrofolate reductase 1.5.1.3 0.666
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.664
1mvt DTMDihydrofolate reductase 1.5.1.3 0.662
3ghw GHWDihydrofolate reductase 1.5.1.3 0.661
1ddr MTXDihydrofolate reductase 1.5.1.3 0.659
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.657
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.654
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.651