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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3itz P66 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3itz P66Mitogen-activated protein kinase 14 / 1.158
3u8w 09JMitogen-activated protein kinase 14 / 0.930
3gfe P37Mitogen-activated protein kinase 14 / 0.920
4kin 1M8Mitogen-activated protein kinase 14 / 0.875
4kip 1R9Mitogen-activated protein kinase 14 / 0.861
3iph G11Mitogen-activated protein kinase 14 / 0.857
4kiq 1RAMitogen-activated protein kinase 14 / 0.857
3fkl FKLMitogen-activated protein kinase 14 / 0.851
3e92 G6AMitogen-activated protein kinase 14 / 0.850
3d7z GK5Mitogen-activated protein kinase 14 / 0.835
3rin I2OMitogen-activated protein kinase 14 / 0.831
3e93 19BMitogen-activated protein kinase 14 / 0.765
3dt1 P40Mitogen-activated protein kinase 14 / 0.754
3s4q NK0Mitogen-activated protein kinase 14 / 0.744
4aa5 NQBMitogen-activated protein kinase 14 / 0.742
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.735
3mvm 39PMitogen-activated protein kinase 14 / 0.734
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.728
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.711
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.707
2rg6 287Mitogen-activated protein kinase 14 / 0.690
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.689
2zb0 GK3Mitogen-activated protein kinase 14 / 0.686
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.673
3bv3 P39Mitogen-activated protein kinase 14 / 0.667
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.664
2bal PQAMitogen-activated protein kinase 14 / 0.663
3ocg OCGMitogen-activated protein kinase 14 / 0.663
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.663
2baq PQBMitogen-activated protein kinase 14 / 0.661
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.660
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.658
3bx5 304Mitogen-activated protein kinase 14 / 0.655
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.651
3cqe P91Wee1-like protein kinase 2.7.10.2 0.650