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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3inv C50 Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3inv C50Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.164
1j3i WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.797
3rg9 WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1j3k WRABifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.732
3um6 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.703
4ddr MMVDihydrofolate reductase 1.5.1.3 0.703
1u70 MTXDihydrofolate reductase 1.5.1.3 0.665
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.663