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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3idb ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.270
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.203
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.192
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.186
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.152
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.149
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.148
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.146
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.113
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.097
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 1.081
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.068
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.023
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.005
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.978
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.974
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.962
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.957
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.955
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.941
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.932
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.930
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.921
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.897
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.880
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.879
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.862
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.857
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.843
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.836
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.830
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.827
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.827
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.826
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.806
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.797
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.793
4ysj ADPCalmodulin-like domain protein kinase / 0.789
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.788
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.783
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.774
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.768
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.766
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.765
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.764
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.764
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.763
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.763
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.760
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.759
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.758
3ori AGSSerine/threonine protein kinase / 0.755
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.753
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.751
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.751
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.745
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.744
5iqh GNPBifunctional AAC/APH 2.3.1 0.743
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.742
3orm AGSSerine/threonine protein kinase / 0.741
2pup ADPMethylthioribose kinase 2.7.1.100 0.737
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.737
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.737
5iqb GNPBifunctional AAC/APH 2.3.1 0.734
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.727
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.726
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.725
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.722
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.722
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.720
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.719
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.718
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.717
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.717
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.716
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.715
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.714
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.714
1cm8 ANPMitogen-activated protein kinase 12 / 0.713
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.712
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.707
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.707
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.707
4qny ANPMitogen activated protein kinase, putative / 0.707
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.704
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.703
5dr2 ATPAurora kinase A 2.7.11.1 0.703
2pml ANPUncharacterized protein / 0.702
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.701
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.701
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.700
5iqa GNPBifunctional AAC/APH 2.3.1 0.700
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.698
5dn3 ATPAurora kinase A 2.7.11.1 0.698
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.696
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.696
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.696
5iqd GNPBifunctional AAC/APH 2.3.1 0.696
1m0w ANPGlutathione synthetase 6.3.2.3 0.695
1mq4 ADPAurora kinase A 2.7.11.1 0.695
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.695
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.693
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.693
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.692
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.691
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.691
5iqf GDPBifunctional AAC/APH 2.3.1 0.691
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.689
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.689
4ceg ADPAurora kinase A 2.7.11.1 0.689
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.688
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
4o4d ATPKinase / 0.687
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.686
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.686
5dt3 ATPAurora kinase A 2.7.11.1 0.686
2wqe ADPAurora kinase A 2.7.11.1 0.685
4n57 ADPAPH(2'')-Id / 0.685
5iqe GNPBifunctional AAC/APH 2.3.1 0.685
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.683
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.683
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
5drd ATPAurora kinase A 2.7.11.1 0.683
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.682
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.682
4dee ADPAurora kinase A 2.7.11.1 0.682
4uxx ACPDiacylglycerol kinase 2.7.1.107 0.681
3cly ACPFibroblast growth factor receptor 2 / 0.680
4utd ACPAurora kinase A 2.7.11.1 0.680
5dos ATPAurora kinase A 2.7.11.1 0.680
2pz5 ACPFibroblast growth factor receptor 2 / 0.679
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.679
3nie ANPMitogen-activated protein kinase / 0.679
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.678
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.676
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.676
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.675
5iqi GNPBifunctional AAC/APH 2.3.1 0.675
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.674
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.674
2vqd AP2Biotin carboxylase 6.3.4.14 0.673
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.673
4ffr ATPUncharacterized protein / 0.673
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.673
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.673
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.672
3c4w ATPRhodopsin kinase / 0.672
3tdv GDPGentamicin resistance protein / 0.672
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
3rv4 ADPBiotin carboxylase 6.3.4.14 0.671
4o0w ADNAurora kinase A 2.7.11.1 0.671
4ork GDPBifunctional AAC/APH 2.3.1 0.671
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.670
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.670
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.670
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
3t8o ATPRhodopsin kinase / 0.669
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.668
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.667
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.667
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.666
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.666
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.665
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.664
2w02 ATPAcsD / 0.664
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 0.663
4o1p ANPRibonuclease L / 0.663
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.662
2pui ADPMethylthioribose kinase 2.7.1.100 0.662
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.662
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.662
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.661
4bn1 ADPAurora kinase A 2.7.11.1 0.661
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.661
5byl GCPBifunctional AAC/APH 2.3.1 0.661
2pul ACPMethylthioribose kinase 2.7.1.100 0.660
3c50 ADPRhodopsin kinase / 0.660
3orl AGSSerine/threonine protein kinase / 0.660
4mv8 ACPBiotin carboxylase 6.3.4.14 0.660
2oo7 AP5Adenylate kinase / 0.659
3c4z ADPRhodopsin kinase / 0.659
3iew CTP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.658
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.657
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.657
2wtk ANPSTE20-related kinase adapter protein alpha / 0.657
4wcx SAMBiotin and thiamin synthesis associated / 0.657
1ir3 ANPInsulin receptor 2.7.10.1 0.656
2py3 ACPFibroblast growth factor receptor 2 / 0.656
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.655
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.655
4zgn ATPCell division cycle protein 123 / 0.655
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.655
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.654
3iew CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.654
5dnr ATPAurora kinase A 2.7.11.1 0.654
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.653
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.653
2eu8 AP5Adenylate kinase / 0.652
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.652
3qc9 ADPRhodopsin kinase / 0.652
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
1mjh ATPUniversal stress protein MJ0577 / 0.651
2qaj AP5Adenylate kinase / 0.651
3tdw GDPGentamicin resistance protein / 0.651
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.651
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.651
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.650
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650
5c1o ANPD-alanine--D-alanine ligase / 0.650