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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hv4 L51 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hv4 L51Mitogen-activated protein kinase 14 / 1.399
3gcu R48Mitogen-activated protein kinase 14 / 1.177
3hv5 R24Mitogen-activated protein kinase 14 / 1.065
3gcv SS6Mitogen-activated protein kinase 14 / 0.958
1w82 L10Mitogen-activated protein kinase 14 / 0.816
3o8u BMUMitogen-activated protein kinase 14 / 0.795
3hv6 R39Mitogen-activated protein kinase 14 / 0.789
3uvr 06FMitogen-activated protein kinase 14 / 0.787
3nnx EDDMitogen-activated protein kinase 14 / 0.785
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.785
3hv7 1AUMitogen-activated protein kinase 14 / 0.763
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.763
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.759
3gcq 1BUMitogen-activated protein kinase 14 / 0.757
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.754
3lff Z83Mitogen-activated protein kinase 14 / 0.746
2yiw YIWMitogen-activated protein kinase 14 / 0.741
2yis YISMitogen-activated protein kinase 14 / 0.739
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.737
3hv3 R49Mitogen-activated protein kinase 14 / 0.735
3nnw EDDMitogen-activated protein kinase 14 / 0.731
3p7c P7CMitogen-activated protein kinase 14 / 0.731
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.731
3lfe Z84Mitogen-activated protein kinase 14 / 0.730
3nnu EDBMitogen-activated protein kinase 14 / 0.730
1w83 L11Mitogen-activated protein kinase 14 / 0.720
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.720
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.720
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.716
1wbt WBTMitogen-activated protein kinase 14 / 0.714
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.711
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.710
3bv2 P38Mitogen-activated protein kinase 14 / 0.704
3p79 P79Mitogen-activated protein kinase 14 / 0.702
2puu G2GMitogen-activated protein kinase 14 / 0.696
1kv1 BMUMitogen-activated protein kinase 14 / 0.694
1kv2 B96Mitogen-activated protein kinase 14 / 0.692
3d83 GK6Mitogen-activated protein kinase 14 / 0.691
3e93 19BMitogen-activated protein kinase 14 / 0.685
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.683
1wbs LI2Mitogen-activated protein kinase 14 / 0.680
4aa4 QC0Mitogen-activated protein kinase 14 / 0.680
3o8t BMUMitogen-activated protein kinase 14 / 0.678
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.676
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.676
3uvp 048Mitogen-activated protein kinase 14 / 0.674
3vnt 0JAVascular endothelial growth factor receptor 2 2.7.10.1 0.674
4aa0 AA0Mitogen-activated protein kinase 14 / 0.671
1wbn L09Mitogen-activated protein kinase 14 / 0.670
2zb0 GK3Mitogen-activated protein kinase 14 / 0.670
3p78 P78Mitogen-activated protein kinase 14 / 0.669
3gi3 B10Mitogen-activated protein kinase 14 / 0.667
3vw9 HPJLactoylglutathione lyase 4.4.1.5 0.665
4kiq 1RAMitogen-activated protein kinase 14 / 0.665
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.664
4aac AAVMitogen-activated protein kinase 14 / 0.662
3p7b P7BMitogen-activated protein kinase 14 / 0.660
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.658
3p7a P7AMitogen-activated protein kinase 14 / 0.656
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.655
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.655
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.654
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.653
4g2i 0VQVitamin D3 receptor / 0.653
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.652
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.652