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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3h7r NAP Aldo-keto reductase family 4 member C8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3h7r NAPAldo-keto reductase family 4 member C8 / 1.521
2pf8 NDPAldose reductase 1.1.1.21 1.225
2pev NDPAldose reductase 1.1.1.21 1.219
2bgs NDPAldose reductase 1.1.1.21 1.218
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.206
1x98 NAPAldose reductase 1.1.1.21 1.191
1x96 NAPAldose reductase 1.1.1.21 1.163
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.148
1z8a NAPAldose reductase 1.1.1.21 1.140
2iq0 NAPAldose reductase 1.1.1.21 1.131
1ads NAPAldose reductase 1.1.1.21 1.119
3q67 NAPAldose reductase 1.1.1.21 1.117
2acq NAPAldose reductase 1.1.1.21 1.114
4pmj NAPPutative oxidoreductase / 1.113
2vdg NDPAldose reductase 1.1.1.21 1.110
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.106
2j8t NAPAldose reductase 1.1.1.21 1.105
2acs NAPAldose reductase 1.1.1.21 1.102
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.100
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.092
5c7h NDPPutative oxidoreductase / 1.092
3wcz NAPAldo-keto reductase AKR2E4 / 1.091
3v36 NAPAldose reductase 1.1.1.21 1.083
1vp5 NAPOxidoreductase, aldo/keto reductase family / 1.071
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.065
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 1.055
4jtq NAPAldo-keto reductase family 1 member C2 / 1.046
2acu NAPAldose reductase 1.1.1.21 1.042
4xo7 NAPAldo-keto reductase family 1 member C2 / 1.028
2pfh NDPAldose reductase 1.1.1.21 1.019
4g5d NDPProstaglandin F synthase 1.1.1.188 1.012
1ef3 NAPAldose reductase 1.1.1.21 1.009
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.009
4l1x NAPAldo-keto reductase family 1 member C2 / 1.006
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.998
2hdj NDPAldo-keto reductase family 1 member C2 / 0.997
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.986
3q65 NAPAldose reductase 1.1.1.21 0.985
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.976
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.973
1ah4 NAPAldose reductase 1.1.1.21 0.971
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.956
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.930
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.924
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.923
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.899
1az2 NAPAldose reductase 1.1.1.21 0.891
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.880
3ln3 NADAldo-keto reductase family 1 member C13 / 0.873
1s1p NAPAldo-keto reductase family 1 member C3 / 0.858
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.857
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.852
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.848
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.835
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.834
1zgd NAPChalcone reductase / 0.825
1s1r NAPAldo-keto reductase family 1 member C3 / 0.797
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.793
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.786
1c9w NAPAldose reductase-related protein 2 / 0.784
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.778
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.778
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.761
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.750
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.740
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.739
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.724
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.716
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.710
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.686
1og6 NAPOxidoreductase YdhF 1 0.679
4jta NAPVoltage-gated potassium channel subunit beta-2 / 0.668
1qrq NDPVoltage-gated potassium channel subunit beta-2 / 0.659