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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3h3f NAI L-lactate dehydrogenase A chain 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.948
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.802
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.788
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.765
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.759
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.754
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.747
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.738
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.734
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.728
2x0i NAIMalate dehydrogenase / 0.728
1pzh NADLactate dehydrogenase / 0.726
2a92 NAIL-lactate dehydrogenase / 0.725
1sow NADL-lactate dehydrogenase 1.1.1.27 0.714
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.711
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.705
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.705
1u7h NADPutative ornithine cyclodeaminase / 0.699
5a1t NAIL-lactate dehydrogenase / 0.697
1x7d NADPutative ornithine cyclodeaminase / 0.695
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.692
1pzg A3DLactate dehydrogenase / 0.691
1pzf A3DLactate dehydrogenase / 0.689
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.688
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.687
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.686
1uxk NADMalate dehydrogenase / 0.686
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.686
1o6z NADMalate dehydrogenase / 0.684
2aa3 AP0L-lactate dehydrogenase / 0.681
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.676
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.674
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.673
4ros APRMalate dehydrogenase / 0.670
1f8f NADBenzyl alcohol dehydrogenase / 0.669
1ie3 NADMalate dehydrogenase / 0.669
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.669
2vwh NAPGlucose 1-dehydrogenase / 0.669
1emd NADMalate dehydrogenase / 0.668
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.667
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.666
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.666
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.664
3wsw NADL-lactate dehydrogenase / 0.664
1gv0 NADMalate dehydrogenase / 0.663
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.661
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.660
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.660
4i1i NADMalate dehydrogenase / 0.659
1bdm NAXMalate dehydrogenase / 0.657
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.657
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.656
2dfv NADL-threonine 3-dehydrogenase / 0.656
2vhx NADAlanine dehydrogenase 1.4.1.1 0.656
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.656
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.655
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
1b8u NADMalate dehydrogenase / 0.654
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.652
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.652
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.651