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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gyu DL7 Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 1.343
3gyt DL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.972
3up0 D7SaceDAF-12 / 0.937
3gki CLRNiemann-Pick C1 protein / 0.757
1ot7 CHCBile acid receptor / 0.713
1lri CLRBeta-elicitin cryptogein / 0.709
3up3 XCAaceDAF-12 / 0.697
4j24 ESTEstrogen receptor beta / 0.696
2b01 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.694
2g5o DRQEstrogen receptor / 0.683
4r21 STRCytochrome P450 family 17 polypeptide 2 / 0.673
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.671
3l03 4OHEstrogen receptor / 0.667
3uud ESTEstrogen receptor / 0.665
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.664
2pkl DHTAndrogen receptor / 0.662
4pxm ESTEstrogen receptor / 0.662
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.658
2aib ERGBeta-elicitin cinnamomin / 0.656
5dx8 SFGHistone-arginine methyltransferase CARM1 / 0.656
2c92 TP66,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.650
3owy EQUSteroid Delta-isomerase 5.3.3.1 0.650
4hlw TESAndrogen receptor / 0.650