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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gyf 51P Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gyf 51PDihydrofolate reductase 1.5.1.3 0.948
3k45 51PDihydrofolate reductase 1.5.1.3 0.809
3l3r OAGDihydrofolate reductase 1.5.1.3 0.730
4ixg IXGDihydrofolate reductase 1.5.1.3 0.729
3nxo D2BDihydrofolate reductase 1.5.1.3 0.715
4g95 OAGDihydrofolate reductase 1.5.1.3 0.714
3oaf OAGDihydrofolate reductase 1.5.1.3 0.708
1hfr MOTDihydrofolate reductase 1.5.1.3 0.702
3qlz QLZUncharacterized protein / 0.694
1m78 CLZDihydrofolate reductase 1.5.1.3 0.688
1dlr MXADihydrofolate reductase 1.5.1.3 0.673
1hfp MOTDihydrofolate reductase 1.5.1.3 0.667
1klk PMDDihydrofolate reductase 1.5.1.3 0.667
3qly 55VUncharacterized protein / 0.666
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.663
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.661
3k47 D09Dihydrofolate reductase 1.5.1.3 0.658
1u70 MTXDihydrofolate reductase 1.5.1.3 0.655
4keb FOLDihydrofolate reductase 1.5.1.3 0.651